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Proteintech
Carboxypeptidase A6 Polyclonal Antibody
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Product Details
13604-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carboxypeptidase A6 Fusion Protein Ag4466 (130-437 aa encoded by BC033684)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SLSGYNYEV YHSLEEIQNW MHHLNKTHSG LIHMFSIGRS YEGRCLFILK LGRRSRLKRA VWIDCGIHAR EWIGPAFCQW FVKEALLTYK SDPAMRKMLN HLYFYIMPVF NVDGYHFSWT NDRFWRKTRS RNSRFRCRGV DANRNWKVKW CDEGASMHPC DDTYCGPFPE SEPEVKAVAN FLRKHRKHIR AYLSFHAYAQ MLLYPYSYKY ATIPNFRCVE SAAYKAVNAL QSVYGVRYRY GPASTTLYVS SGSSMDWAYK NGIPYAFAFE LRDTGYFGFL LPEMLIKPTC TETMLAVKNI TMHLLKKCP (130-437 aa encoded by BC033684)
Target Information
Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. As a member of the A/B subfamily, CPA6 (Carboxypeptidase A6) is a 437 amino acid secreted, zinc-binding protein that contains a characteristic propetide at the amino terminus, which is cleaved off upon enzyme activation. Although expressed broadly in embryonic tissues, CPA6 is found at highest levels in the adult olfactory bulb and epididymus. CPA6 functions to cleave large C-terminal hydrophobic residues off of proteins and protein substrates and is likely involved in the extracellular processing of neuropeptides. Mutations in the gene encoding CPA6 have been linked to Duane syndrome, a congential eye-movement disorder characterized by the abnormal development of cranial nerve VI (the abducens nerve). There are three isoforms of CPA6 that exist as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Carboxypeptidase A6; carboxypeptidase B; metallocarboxypeptidase
Gene Aliases: 9030616D13Rik; CPA6; CPAH; ETL5; FEB11
UniProt ID: (Human) Q8N4T0, (Mouse) Q5U901
Entrez Gene ID: (Human) 57094, (Mouse) 329093, (Rat) 312913
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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