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Proteintech
Carboxypeptidase B2 Polyclonal Antibody
Product Details
10672-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carboxypeptidase B2 Fusion Protein Ag1110 (119-423 aa encoded by BC007057)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YYEQYHSLN EIYSWIEFIT ERHPDMLTKI HIGSSFEKYP LYVLKVSGKE QAAKNAIWID CGIHAREWIS PAFCLWFIGH ITQFYGIIGQ YTNLLRLVDF YVMPVVNVDG YDYSWKKNRM WRKNRSFYAN NHCIGTDLNR NFASKHWCEE GASSSSCSET YCGLYPESEP EVKAVASFLR RNINQIKAYI SMHSYSQHIV FPYSYTRSKS KDHEELSLVA SEAVRAIEKT SKNTRYTHGH GSETLYLAPG GGDDWIYDLG IKYSFTIELR DTGTYGFLLP ERYIKPTCRE AFAAVSKIAW HVIRNV (119-423 aa encoded by BC007057)
Target Information
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for its gene and its promoter region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: carboxypeptidase B-like protein; Carboxypeptidase B2; carboxypeptidase B2 (plasma); carboxypeptidase B2 (plasma, carboxypeptidase U); Carboxypeptidase R; Carboxypeptidase U; CPR; CPU; pCPB; Plasma carboxypeptidase B; TAFI; Thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor
Gene Aliases: 1110032P04Rik; 4930405E17Rik; AI255929; CPB2; CPR; CPU; PCPB; TAFI
UniProt ID: (Human) Q96IY4, (Mouse) Q9JHH6, (Rat) Q9EQV9
Entrez Gene ID: (Human) 1361, (Mouse) 56373, (Rat) 113936
positive regulation of extracellular matrix constituent secretion
proteolysis
blood coagulation
response to heat
negative regulation of plasminogen activation
response to drug
fibrinolysis
negative regulation of fibrinolysis
cellular response to glucose stimulus
liver regeneration
negative regulation of hepatocyte proliferation
hemostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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