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Invitrogen
Carboxypeptidase E Polyclonal Antibody
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Carboxypeptidase E Antibody (PA5-109581) in WB
Western blot analysis of Carboxypeptidase E in extracts of various cell lines. Samples were incubated with Carboxypeptidase E Polyclonal antibody (Product # PA5-109581) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-109581
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 257-476 of human CPE (NP_001864.1).
Conjugate
Form
Liquid
Concentration
1.68 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2854992
Product Specific Information
Immunogen sequence: PYDETRSGSA HEYSSSPDDA IFQSLARAYS SFNPAMSDPN RPPCRKNDDD SSFVDGTTNG GAWYSVPGGM QDFNYLSSNC FEITVELSCE KFPPEETLKT YWEDNKNSLI SYLEQIHRGV KGFVRDLQGN PIANATISVE GIDHDVTSAK DGDYWRLLIP GNYKLTASAP GYLAITKKVA VPYSPAAGVD FELESFSERK EEEKEELMEW WKMMSETLNF
Target Information
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Carboxypeptidase E; Carboxypeptidase H; CarboxypeptidaseE; CarboxypeptidaseH; CBPE; cobalt-stimulated chromaffin granule carboxypeptidase; CPE; CPH; Cph 1; Enkephalin convertase; insulin granule-associated carboxypeptidase; Prohormone-processing carboxypeptidase
Gene Aliases: CPE; CPH; Cph-1; Cph1; fat; R74677
UniProt ID: (Human) P16870, (Mouse) Q00493
Entrez Gene ID: (Human) 1363, (Mouse) 12876
carboxypeptidase activity
metallocarboxypeptidase activity
serine-type carboxypeptidase activity
zinc ion binding
neurexin family protein binding
cell adhesion molecule binding
peptidase activity
metallopeptidase activity
hydrolase activity
protein domain specific binding
metal ion binding
cobalt ion binding
cardiac left ventricle morphogenesis
cellular protein modification process
neuropeptide signaling pathway
metabolic process
Wnt signaling pathway
insulin processing
protein localization to membrane
proteolysis
peptide metabolic process
protein processing
enkephalin processing
peptide catabolic process
negative regulation of branching morphogenesis of a nerve
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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