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Invitrogen
Carboxypeptidase E Polyclonal Antibody
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Carboxypeptidase E Antibody (PA5-28376) in IHC (P)
Carboxypeptidase E Polyclonal Antibody detects Carboxypeptidase E protein at nucleus on human breast cancer by immunohistochemical analysis. Sample: Paraffin-embedded breast cancer. Carboxypeptidase E Polyclonal Antibody (Product # PA5-28376) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-28376
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Carboxypeptidase E. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.68 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2545852
Product Specific Information
Recommended positive controls: Carboxypeptidase H tansfected 293T cell, mouse brain.
Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (85%), Xenopus laevis (83%), Pig (95%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Carboxypeptidase E; Carboxypeptidase H; CarboxypeptidaseE; CarboxypeptidaseH; CBPE; cobalt-stimulated chromaffin granule carboxypeptidase; CPE; CPH; Cph 1; Enkephalin convertase; insulin granule-associated carboxypeptidase; Prohormone-processing carboxypeptidase
Gene Aliases: CPE; CPH; Cph-1; Cph1; fat; R74677
UniProt ID: (Human) P16870, (Mouse) Q00493
Entrez Gene ID: (Human) 1363, (Mouse) 12876
carboxypeptidase activity
metallocarboxypeptidase activity
serine-type carboxypeptidase activity
zinc ion binding
neurexin family protein binding
cell adhesion molecule binding
peptidase activity
metallopeptidase activity
hydrolase activity
protein domain specific binding
metal ion binding
cobalt ion binding
cardiac left ventricle morphogenesis
cellular protein modification process
neuropeptide signaling pathway
metabolic process
Wnt signaling pathway
insulin processing
protein localization to membrane
proteolysis
peptide metabolic process
protein processing
enkephalin processing
peptide catabolic process
negative regulation of branching morphogenesis of a nerve
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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