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NeoBiotechnologies
Carcinoembryonic Antigen (CEA)/CD66 Monoclonal Antibody (COL-1)
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Product Details
1048-MSM1-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
COL-1
Immunogen
Human colon carcinoma extract
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The CD66 molecules are 180-200 kDa glycoproteins of carcinoembryonic antigen family. They are present on all blood granulocytes and some tissue macrophages, but are absent from other hematopoietic cells. The expression of CD66 increases significantly on granulocytes upon their activation. CD66a (BGP1, CEACAM1) and CD66d (CGM1, CEACAM3), as well as CEACAM2 and 4, are transmembrane proteins, whereas CD66c (CEAL, NCA, CEACAM6) and CD66e (CEA, CEACAM5), as well as CEACAM7 and 8, are anchored to the plasma membrane by C-terminal glycosylphosphatidylinositol (GPI) lipid moiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen; Carcinoembryonic antigen CGM1; Carcinoembryonic antigen CGM7; carcinoembryonic antigen gene family member 1; carcinoembryonic antigen gene family member 7; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 3; Carcinoembryonic antigen-related cell adhesion molecule 4; carcinoembryonic antigen-related cell adhesion molecule 4-sv1; carcinoembryonic antigen-related cell adhesion molecule 4-sv2; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); CD66a; CD66a antigen; CD66c; CD66d; CD66d antigen; CD66e; CEA; CEA cell adhesion molecule 1; CEA cell adhesion molecule 3; CEA cell adhesion molecule 4; CEA cell adhesion molecule 5; CEA cell adhesion molecule 6; CEACAM-1; CEACAM-3; CEACAM-5; CEACAM-6; Cell adhesion molecule CEACAM1; Cell adhesion molecule CEACAM3; Cell adhesion molecule CEACAM4; Cell adhesion molecule CEACAM5; Cell adhesion molecule CEACAM6; Cluster of Differentiation 66c; Meconium antigen 100; Non-specific cross-reacting antigen W236; Non-specific crossreacting antigen; nonspecific cross-reacting antigen; Nonspecific cross-reacting antigen (NCA); nonspecific cross-reacting antigen W236; Normal cross-reacting antigen; pan CEACAM
Gene Aliases: BGP; BGP1; BGPI; CD66c; CD66D; CD66e; CEA; CEACAM1; CEACAM3; CEACAM4; CEACAM5; CEACAM6; CEAL; CGM1; CGM7; CGM7_HUMAN; NCA; W264; W282
UniProt ID: (Human) P13688, (Human) P40198, (Human) O75871, (Human) P06731, (Human) P40199
Entrez Gene ID: (Human) 634, (Human) 1084, (Human) 1089, (Human) 1048, (Human) 4680
phagocytosis
angiogenesis
regulation of cell growth
blood vessel development
negative regulation of T cell mediated cytotoxicity
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
negative regulation of protein kinase activity
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
integrin-mediated signaling pathway
regulation of endothelial cell migration
regulation of phosphatidylinositol 3-kinase signaling
bile acid and bile salt transport
cell migration
regulation of cell migration
negative regulation of granulocyte differentiation
negative regulation of interleukin-1 production
cellular response to insulin stimulus
common myeloid progenitor cell proliferation
insulin receptor internalization
granulocyte colony-stimulating factor signaling pathway
regulation of epidermal growth factor receptor signaling pathway
negative regulation of vascular permeability
negative regulation of cytotoxic T cell degranulation
wound healing, spreading of cells
regulation of endothelial cell differentiation
negative regulation of fatty acid biosynthetic process
negative regulation of T cell receptor signaling pathway
leukocyte migration
negative regulation of lipid biosynthetic process
regulation of blood vessel remodeling
regulation of ERK1 and ERK2 cascade
negative regulation of platelet aggregation
cell-cell adhesion
insulin catabolic process
regulation of homophilic cell adhesion
regulation of sprouting angiogenesis
negative regulation of hepatocyte proliferation
positive regulation of vasculogenesis
signal transduction
cell-cell signaling
negative regulation of myotube differentiation
homotypic cell-cell adhesion
negative regulation of apoptotic process
negative regulation of anoikis
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