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Invitrogen
Cardiac Troponin C Polyclonal Antibody
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FIGURE: 1 / 8
Cardiac Troponin C Antibody (PA5-119941) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of of TNNC1 in SKOV-3 cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with Cardiac Troponin C Polyclonal Antibody (Product # PA5-119941) at a dilution of 1:100 for 1 hour at room temperature, washed with ... View More
Product Details
PA5-119941
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length protein of human TNNC1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913513
Product Specific Information
Positive Control: Human heart tissue lysates, MG-63, SKOV-3, SW620, rat skeletal muscle tissue, rat heart tissue, mouse heart tissue.
Subcellular Location: Cardiac Troponin complex, troponin complex, cytosol.
Target Information
Troponin (Tn) is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments, and as a result of calcium-ion uptake by troponin-C, the elements of the muscle thin filament undergo a series of allosteric changes which allow the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiac 3; cardiac troponin C; Cardiac troponin I; CMD1FF; CMD2A; CMH7; MGC116817; RCM1; slow twitch skeletal/cardiac muscle troponin C; TN-C; Tn1; Tni; TNN I3; TNNC 1; TNNI3; troponin C type 1 (slow); troponin C, cardiac/slow skeletal; Troponin C, slow skeletal and cardiac muscles; troponin C1, slow; Troponin I; Troponin I cardiac; TroponinI
Gene Aliases: AI874626; CMD1Z; CMH13; cTnC; cTnI; TN-C; TNC; Tncc; TNNC; TNNC1
UniProt ID: (Human) P63316, (Mouse) P19123
Entrez Gene ID: (Human) 7134, (Rat) 290561, (Mouse) 21924
diaphragm contraction
skeletal muscle contraction
regulation of muscle contraction
response to metal ion
transition between fast and slow fiber
muscle filament sliding
regulation of muscle filament sliding speed
regulation of ATPase activity
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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