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Invitrogen
Cardiac Troponin I Recombinant Rabbit Monoclonal Antibody (4B8G2)
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Product Details
MA5-51476
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4B8G2
Immunogen
Recombinant protein of human Cardiac Troponin I (TNNI3).
Conjugate
Form
Liquid
Concentration
1.4 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3094153
Target Information
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); MGC116817; Tpn1; troponin 1, type 3; troponin I type 3 (cardiac); Troponin I, cardiac muscle
Gene Aliases: CMD1FF; CMD2A; CMH7; Ctni; RCM1; Tn1; TnI; TNNC1; TNNI3
UniProt ID: (Human) P19429, (Rat) P23693, (Mouse) P48787
Entrez Gene ID: (Human) 7137, (Rat) 29248, (Mouse) 21954
vasculogenesis
regulation of systemic arterial blood pressure by ischemic conditions
cellular calcium ion homeostasis
regulation of muscle contraction
regulation of smooth muscle contraction
striated muscle contraction
heart development
negative regulation of ATPase activity
ventricular cardiac muscle tissue morphogenesis
heart contraction
cardiac muscle contraction
skeletal muscle contraction
muscle filament sliding
regulation of cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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