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Invitrogen
Cardiac Troponin T Monoclonal Antibody (1F11)
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FIGURE: 1 / 2
Cardiac Troponin T Antibody (MA1-24612) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of tissue extracts (30 µg lysate) of Mouse Heart (Lane 1), Rat Heart (Lane 2), Mouse Skeletal Muscle (Lane 3) and Rat Skeletal Muscle (Lane 4). The blot was probed with Anti-Cardiac Troponin T Monoclonal Antibody (1F11) (Product # MA1-24612, 1:500 dilution) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25 µg/ml, 1:4000 dilution). A 40 kDa band corresponding to Cardiac Troponin T w... View More
Product Details
MA1-24612
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Cat,
Fish,
Goat,
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1F11
Immunogen
Free human cTnT.
Conjugate
Form
Liquid
Concentration
4.3 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2206583
Product Specific Information
MA1-24612 detects a band at approximately 35.4 kDa.
Target Information
Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiac muscle troponin T; cardiac TnT; cardiac troponin T; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; cTnT; MGC3889; TnTc; Troponin T cardiac; troponin T cardiac isoform; troponin T type 2 (cardiac); Troponin T, cardiac muscle; Troponin T2; troponin T2, cardiac; truncated cardiac troponin T
Gene Aliases: BOS_15864; CMD1D; CMH2; CMPD2; cTnT; Ctt; CTTG; LVNC6; RATCTTG; RCM3; TNNT2; Tnnt3; Tnt; TnTC
UniProt ID: (Human) P45379, (Rat) P50753, (Mouse) P50752
Entrez Gene ID: (Goat) 102185261, (Human) 7139, (Rabbit) 100009428, (Pig) 100622450, (Bovine) 286816, (Dog) 403532, (Cat) 493940, (Rat) 24837, (Mouse) 21956
regulation of heart contraction
muscle filament sliding
negative regulation of ATPase activity
positive regulation of ATPase activity
regulation of muscle filament sliding speed
protein heterooligomerization
response to calcium ion
actin crosslink formation
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
muscle contraction
regulation of muscle contraction
heart development
metabolic process
sarcomere organization
atrial cardiac muscle tissue morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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