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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Caspase 12 Antibodies

          Proteintech

          Caspase 12 Polyclonal Antibody

          92 References
          View all (27) Caspase 12 antibodies

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          Datasheet
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          Datasheet
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          Cite Caspase 12 Polyclonal Antibody

          • Antibody Testing Data (11)
          Caspase 12 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Caspase 12 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 11

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          Caspase 12 Antibody (55238-1-AP) in ICC/IF

          Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 55238-1-AP (Caspase 12 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Caspase 12 Antibody in Immunocytochemistry (ICC/IF)
          Caspase 12 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caspase 12 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caspase 12 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caspase 12 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caspase 12 Antibody in Western Blot (WB)
          Caspase 12 Antibody in Western Blot (WB)
          Caspase 12 Antibody in Western Blot (WB)
          Caspase 12 Antibody in Western Blot (WB)
          Caspase 12 Antibody in Western Blot (WB)
          Caspase 12 Antibody in Immunoprecipitation (IP)

          Product Details

          55238-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 80 publications 80 publications

          Immunohistochemistry (IHC)

          -
          View 4 publications 4 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:500
          View 4 publications 4 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          -

          Miscellaneous PubMed (MISC)

          -
          View 2 publications 2 publications

          Not applicable (N/A)

          -
          View 2 publications 2 publications
          Product Specifications

          Species Reactivity

          Human

          Published species

          Hamster, Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Peptide

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.4 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          This antibody does not cross-react with other caspases.

          Target Information

          Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: CASP-12; caspase 12 pseudogene 1; Inactive caspase-12; OTTMUSP00000045799; OTTMUSP00000045802; OTTMUSP00000045803; UNQ9415

          View more View less

          Gene Aliases: CASP-12; CASP12; CASP12P1; UNQ9415/PRO34398

          View more View less

          UniProt ID: (Human) Q6UXS9

          View more View less

          Entrez Gene ID: (Human) 100506742

          View more View less

          Function(s)
          cysteine-type endopeptidase activity involved in apoptotic process
          Process(es)
          endoplasmic reticulum unfolded protein response regulation of apoptotic process regulation of inflammatory response intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress self proteolysis
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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