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Invitrogen
Caspase 13 Polyclonal Antibody
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Product Details
PA5-19949
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide near the amino terminus of bovine Caspase-13
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Ion-exchange chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152616
Product Specific Information
In Western blot applications, this antibody detects a band at ~43kDa.
A suggested positive control is HL60 cell lysate.
PA5-19949 can be used with blocking peptide PEP-0074.
The immunogen is located within amino acids 80 - 130 of Caspase-13.
Target Information
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptotic cysteine protease Mih1/TX; CASP-11; CASP-13; CASP-4; CASP13; caspase 11; caspase 13; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-11; Caspase-13; Caspase-4; ERICE; Evolutionary related interleukin-1-beta-converting enzyme; ICE and Ced-3 homolog 2; ICE(rel)-II; ICH-2; MGC137679; Mih1; protease ICH-2; Protease ICH-3; Protease TX
Gene Aliases: BOS_14235; CASP-11; CASP-4; Casp11; CASP13; CASP4; Caspl; ICE(rel)II; ICEREL-II; ICH-2; ich-3; ICH2; Ich3; Mih1; Mih1/TX; TX
UniProt ID: (Bovine) O75601, (Human) P49662, (Mouse) P70343
Entrez Gene ID: (Bovine) 338039, (Human) 837, (Rat) 114555, (Mouse) 12363
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
substantia nigra development
ectopic germ cell programmed cell death
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
pyroptosis
cellular response to mechanical stimulus
execution phase of apoptosis
negative regulation of apoptotic process
regulation of apoptotic process
innate immune response
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
intrinsic apoptotic signaling pathway
cellular response to beta-amyloid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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