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Proteintech
Caspase 2/p32/p18 Monoclonal Antibody (2G4C2), CoraLite® Plus 488
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Product Details
CL488-66517
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2G4C2
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: GPLCLQVKPC TPEFYQTHFQ LAYRLQSRPR GLALVLSNVH FTGEKELEFR SGGDVDHSTL VTLFKLLGYD VHVLCDQTAQ EMQEKLQNFA QLPAHRVTDS CIVALLSHGV EGAIYGVDGK LLQLQEVFQL FDNANCPSLQ NKPKMFFIQA CRGDET
Target Information
Caspase 2 is an enzyme that plays a crucial role in programmed cell death, also known as apoptosis. It exists in two forms, p32 and p18, which refer to different subunits of the caspase 2 protein. The p32 subunit is the larger subunit of caspase 2 and contains the catalytic domain responsible for the enzymatic activity of caspase 2. This domain allows caspase 2 to cleave specific proteins involved in apoptosis, leading to cell death. When cells are induced to undergo apoptosis, endogenous caspase-2 is first cleaved into three fragments of 32-33 kDa and 14 kDa, which are then further processed into 18- and 12-kDa active subunits. The p32 subunit is essential for the activation and execution of caspase 2-mediated apoptosis. The p18 subunit, on the other hand, is the smaller subunit of caspase 2. It acts as a regulatory subunit and is involved in the activation of caspase 2. The p18 subunit assists in the formation of the active caspase 2 complex and helps initiate the apoptotic signaling cascade.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CASP-2; caspase 2 apoptosis-related cysteine peptidase; Caspase-2; NEDD-2; Neural precursor cell expressed developmentally down-regulated protein 2; Protease ICH-1; protein phosphatase 1, regulatory subunit 57
Gene Aliases: CASP-2; CASP2; ICH1; NEDD-2; NEDD2; PPP1R57
UniProt ID: (Human) P42575
Entrez Gene ID: (Human) 835
luteolysis
neural retina development
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
brain development
aging
intrinsic apoptotic signaling pathway in response to DNA damage
protein processing
ectopic germ cell programmed cell death
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
cellular response to mechanical stimulus
apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
execution phase of apoptosis
positive regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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