Proteintech

Caspase 4/p20/p10 Polyclonal Antibody

11 References

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (4)

Caspase 4/p20/p10 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

Caspase 4/p20/p10 Antibody (11856-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 11856-1-AP (Caspase 4/p20/p10 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Caspase 4/p20/p10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Caspase 4/p20/p10 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

11856-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Caspase 4/p20/p10 Fusion Protein Ag2429 (1-377 aa encoded by BC017839)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEGNHRKK PLKVLESLGK DFLTGVLDNL VEQNVLNWKE EEKKKYYDAK TEDKVRVMAD SMQEKQRMAG QMLLQTFFNI DQISPNKKAH PNMEAGPPES GESTDALKLC PHEEFLRLCK ERAEEIYPIK ERNNRTRLAL IICNTEFDHL PPRNGADFDI TGMKELLEGL DYSVDVEENL TARDMESALR AFATRPEHKS SDSTFLVLMS HGILEGICGT VHDEKKPDVL LYDTIFQIFN NRNCLSLKDK PKVIIVQACR GANRGELWVR DSPASLEVAS SQSSENLEED AVYKTHVEKD FIAFCSSTPH NVSWRDSTMG SIFITQLITC FQKYSWCCHL EEVFRKVQQS FETPRAKAQM PTIERLSMTR YFYLFPGN (1-377 aa encoded by BC017839)

Target Information

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

International journal of general medicine

Zhou Z,Xu J,Huang N,Tang J,Ma P,Cheng Y

Sat Jul 16 00:00:00 UTC 2022

Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma.

Frontiers in immunology

Fu L,Bao J,Li J,Li Q,Lin H,Zhou Y,Li J,Yan Y,Langston ME,Sun T,Guo S,Zhou X,Chen Y,Liu Y,Zhao Y,Lu J,Huang Y,Chen W,Chung BI,Luo J

Tue Oct 18 00:00:00 UTC 2022

Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma.

Frontiers in immunology

Fu L,Bao J,Li J,Li Q,Lin H,Zhou Y,Li J,Yan Y,Langston ME,Sun T,Guo S,Zhou X,Chen Y,Liu Y,Zhao Y,Lu J,Huang Y,Chen W,Chung BI,Luo J

Tue Oct 18 00:00:00 UTC 2022

Enterovirus 71 Induces INF2 Cleavage via Activated Caspase-2 in Infected RD Cells.

Frontiers in microbiology

Wang B,Zhang C,Yu C,Zhu Y,Tang Q,Huang H,Zhao Z

Sun May 30 00:00:00 UTC 2021

IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.

Experimental and therapeutic medicine

Wang J,Yuan X,Ding N

Tue Jun 01 00:00:00 UTC 2021

Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.

Inflammation

Ji Q,Wang L,Liu J,Wu Y,Lv H,Wen Y,Shi L,Qu B,Szentmáry N

Thu Apr 01 00:00:00 UTC 2021

The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors.

Stem cells international

Jiao Y,Wang L,Lu L,Liu J,Li X,Zhao H,Hou Z,Zheng B

Mon Sep 28 00:00:00 UTC 2020

Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.

Frontiers in microbiology

Ding PH,Yang MX,Wang NN,Jin LJ,Dong Y,Cai X,Chen LL

Mon Sep 28 00:00:00 UTC 2020

Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line.

Medical science monitor : international medical journal of experimental and clinical research

Xin XL,Zhang R,Yuan XM,Liu L

Sun Sep 22 00:00:00 UTC 2019

Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation.

Chemical research in toxicology

Xia X,Lu B,Dong W,Yang B,Wang Y,Qin Q,Liu Z,Song E,Song Y

Mon Dec 17 00:00:00 UTC 2018

Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation.

Chemical research in toxicology

Xia X,Lu B,Dong W,Yang B,Wang Y,Qin Q,Liu Z,Song E,Song Y

Mon Dec 17 00:00:00 UTC 2018

Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.

International journal of molecular sciences

Shi WY,Cao C,Liu L

Wed Nov 02 00:00:00 UTC 2016

Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.

International journal of molecular sciences

Shi WY,Cao C,Liu L

Wed Nov 02 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: apoptotic cysteine protease Mih1/TX; CASP-4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-4; ICE and Ced-3 homolog 2; ICE(rel)-II; ICH-2; Mih1; protease ICH-2; Protease TX

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Gene Aliases: CASP4; ICE(rel)II; ICEREL-II; ICH-2; ICH2; Mih1; Mih1/TX; TX

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UniProt ID: (Human) P49662

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Entrez Gene ID: (Human) 837

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Function(s)

cysteine-type endopeptidase activity involved in apoptotic process

Process(es)

proteolysis apoptotic process inflammatory response regulation of apoptotic process innate immune response regulation of inflammatory response intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway cellular response to beta-amyloid

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Caspase 4/p20/p10 Polyclonal Antibody

Caspase 4/p20/p10 Antibody (11856-1-AP) in ICC/IF

Product Details

11856-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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