Proteintech

Caspase 6/p18/p11 Polyclonal Antibody

12 References

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (14)

Caspase 6/p18/p11 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 14

Caspase 6/p18/p11 Antibody (10198-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer using 10198-1-AP (CASP6 antibody) at dilution of 1:50 (under 10x lens).

Caspase 6/p18/p11 Antibody in Western Blot (WB)

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Product Details

10198-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Caspase 6/p18/p11 Fusion Protein Ag0257 (59-222 aa encoded by BC000305)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LTLPERRGT CADRDNLTRR FSDLGFEVKC FNDLKAEELL LKIHEVSTVS HADADCFVCV FLSHGEGNHI YAYDAKIEIQ TLTGLFKGDK CHSLVGKPKI FIIQACRGNQ HDVPVIPLDV VDNQTEKLDT NITEVDAASV YTLPAGADFL MCYSVAEGYY SHRET (59-222 aa encoded by B C000305)

Target Information

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway.

Acta pharmacologica Sinica

Liang JP,He YM,Cui YL,Sun YN,He GS,Zhu ZG,Mao XL

Sat Jul 01 00:00:00 UTC 2023

Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.

Translational stroke research

Lu D,Liu Y,Huang H,Hu M,Li T,Wang S,Shen S,Wu R,Cai W,Lu T,Lu Z

Fri Dec 01 00:00:00 UTC 2023

Involvement of caspase in patulin-induced hepatotoxicity in vitro and in vivo.

Toxicon : official journal of the International Society on Toxinology

Zhang B,Huang C,Lu Q,Liang H,Li J,Xu D

Sun Jan 30 00:00:00 UTC 2022

Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-A^Thr288-geminin dual signaling pathways.

Frontiers in pharmacology

Zhao H,Jia P,Nanding K,Wu M,Bai X,Morigen M,Fan L

Tue Sep 10 00:00:00 UTC 2024

Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.

Frontiers in pharmacology

Yang M,Li WY,Xie J,Wang ZL,Wen YL,Zhao CC,Tao L,Li LF,Tian Y,Sheng J

Sat May 08 00:00:00 UTC 2021

Enterovirus 71 Induces INF2 Cleavage via Activated Caspase-2 in Infected RD Cells.

Frontiers in microbiology

Wang B,Zhang C,Yu C,Zhu Y,Tang Q,Huang H,Zhao Z

Sun May 30 00:00:00 UTC 2021

The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats.

Drug design, development and therapy

Hou W,Hao Y,Yang W,Tian T,Fang P,Du Y,Gao L,Gao Y,Zhang Q

Fri Jan 28 00:00:00 UTC 2022

Excessive mechanical stress induces chondrocyte apoptosis through TRPV4 in an anterior cruciate ligament-transected rat osteoarthritis model.

Life sciences

Xu B,Xing R,Huang Z,Yin S,Li X,Zhang L,Ding L,Wang P

Mon Jul 01 00:00:00 UTC 2019

Jieduan-Niwan Formula Reduces Liver Apoptosis in a Rat Model of Acute-on-Chronic Liver Failure by Regulating the E2F1-Mediated Intrinsic Apoptosis Pathway.

Evidence-based complementary and alternative medicine : eCAM

Yang W,Hao Y,Hou W,Fang X,Fang P,Jiang T,Ma C,Zhang Q

Mon Jul 22 00:00:00 UTC 2024

Generation of apoptosis-resistant HEK293 cells with CRISPR/Cas mediated quadruple gene knockout for improved protein and virus production.

Biotechnology and bioengineering

Zhang W,Xiao D,Shan L,Zhao J,Mao Q,Xia H

Wed Nov 01 00:00:00 UTC 2017

Generation of apoptosis-resistant HEK293 cells with CRISPR/Cas mediated quadruple gene knockout for improved protein and virus production.

Biotechnology and bioengineering

Zhang W,Xiao D,Shan L,Zhao J,Mao Q,Xia H

Wed Nov 01 00:00:00 UTC 2017

Gelsolin-like actin-capping protein is associated with patient prognosis, cellular apoptosis and proliferation in prostate cancer.

Biomarkers in medicine

Li T,Hong X,Zhao J,Teng Y,Zheng J,Chen H,Chen H,Li H

Thu Dec 01 00:00:00 UTC 2016

Gelsolin-like actin-capping protein is associated with patient prognosis, cellular apoptosis and proliferation in prostate cancer.

Biomarkers in medicine

Li T,Hong X,Zhao J,Teng Y,Zheng J,Chen H,Chen H,Li H

Thu Dec 01 00:00:00 UTC 2016

O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.

Chemico-biological interactions

Liao H,Bao X,Zhu J,Qu J,Sun Y,Ma X,Wang E,Guo X,Kang Q,Zhen Y

Sat Dec 05 00:00:00 UTC 2015

O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.

Chemico-biological interactions

Liao H,Bao X,Zhu J,Qu J,Sun Y,Ma X,Wang E,Guo X,Kang Q,Zhen Y

Sat Dec 05 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Apoptotic protease Mch-2; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6

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Gene Aliases: CASP-6; CASP6; MCH2

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UniProt ID: (Human) P55212, (Mouse) O08738

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Entrez Gene ID: (Human) 839, (Mouse) 12368, (Rat) 83584

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Function(s)

cysteine-type endopeptidase activity protein binding cysteine-type peptidase activity identical protein binding cysteine-type endopeptidase activity involved in apoptotic process endopeptidase activity

Process(es)

lens development in camera-type eye acute inflammatory response to non-antigenic stimulus proteolysis apoptotic process response to heat response to glucose response to organic substance response to metal ion response to iron ion response to organonitrogen compound response to gamma radiation epithelial cell differentiation response to estradiol response to testosterone response to cytokine response to hydrogen peroxide positive regulation of apoptotic process positive regulation of neuron apoptotic process positive regulation of retinal cell programmed cell death cellular component disassembly involved in execution phase of apoptosis regulation of apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Caspase 6/p18/p11 Polyclonal Antibody

Caspase 6/p18/p11 Antibody (10198-1-AP) in IHC (P)

Product Details

10198-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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