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Bioss
Caspase-6 subunit p11 Polyclonal Antibody
FIGURE: 1 / 3
Caspase-6 subunit p11 Antibody (BS-10135R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Caspase-6 subunit p11 Polyclonal Antibody, Unconjugated (bs-10135R) at 1:400 overnight at 4°C, DAB staining.
Product Details
BS-10135R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Caspase-6 subunit p11, amino acids 181-293.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Caspase-6 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Subunit is compose of heterodimer of a18 kDa (p18) and a 11 kDa (p11) subunit. Subcellular location at cytoplasmic. Cleavages by CPP32, caspase-8 or -10 generate the two active subunits. It belongs to the peptidase C14 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptotic protease Mch-2; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6
Gene Aliases: CASP-6; CASP6; MCH2
UniProt ID: (Human) P55212, (Mouse) O08738
Entrez Gene ID: (Human) 839, (Mouse) 12368, (Rat) 83584
lens development in camera-type eye
acute inflammatory response to non-antigenic stimulus
proteolysis
apoptotic process
response to heat
response to glucose
response to organic substance
response to metal ion
response to iron ion
response to organonitrogen compound
response to gamma radiation
epithelial cell differentiation
response to estradiol
response to testosterone
response to cytokine
response to hydrogen peroxide
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of retinal cell programmed cell death
cellular component disassembly involved in execution phase of apoptosis
regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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