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Cathelicidin Antibody (PA5-102898) in IHC (P)
Immunohistochemistry analysis of Cathelicidin in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Cathelicidin polyclonal antibody (Product # PA5-102898) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102898
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CAMP(Accession P49913), corresponding to amino acid residues I43-S93.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852279
Product Specific Information
Antibody detects endogenous levels of total Cathelicidin.
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis and neutrophils. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 18 kDa cationic antimicrobial protein; CAP-18; Cathelicidin antimicrobial peptide; Cathelin-like protein; cathelin-related antimicrobial peptide; CLP; hCAP-18; hCAP18
Gene Aliases: CAMP; CAP-18; CAP18; Cnlp; CRAMP; FALL-39; FALL39; HSD26; LL37; MCLP
UniProt ID: (Human) P49913, (Mouse) P51437
Entrez Gene ID: (Human) 820, (Rat) 316010, (Mouse) 12796
innate immune response in mucosa
antibacterial humoral response
defense response to bacterium
negative regulation of growth of symbiont on or near host surface
cell redox homeostasis
defense response to Gram-positive bacterium
killing by host of symbiont cells
positive regulation of protein phosphorylation
positive regulation of cell proliferation
negative regulation of endopeptidase activity
negative regulation of growth of symbiont in host
positive regulation of angiogenesis
defense response to Gram-negative bacterium
cellular response to lipopolysaccharide
cellular response to peptidoglycan
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
defense response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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