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Proteintech
Cathepsin A Polyclonal Antibody
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Product Details
15020-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cathepsin A Fusion Protein Ag7073 (133-479 aa encoded by BC000597)
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FSYSDDKFY ATNDTEVAQS NFEALQDFFR LFPEYKNNKL FLTGESYAGI YIPTLAVLVM QDPSMNLQGL AVGNGLSSYE QNDNSLVYFA YYHGLLGNRL WSSLQTHCCS QNKCNFYDNK DLECVTNLQE VARIVGNSGL NIYNLYAPCA GGVPSHFRYE KDTVVVQDLG NIFTRLPLKR MWHQALLRSG DKVRMDPPCT NTTAASTYLN NPYVRKALNI PEQLPQWDMC NFLVNLQYRR LYRSMNSQYL KLLSSQKYQI LLYNGDVDMA CNFMGDEWFV DSLNQKMEVQ RRPWLVKYGD SGEQIAGFVK EFSHIAFLTI KGAGHMVPTD KPLAAFTMFS RFLNKQPY (133-479 aa encoded by BC000597)
Target Information
The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyle protease class. The serine protease class includes cathepsin G. Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with b-galactosidase (b-gal) and a-neuraminidase (Neu1). Cathepsin A functions to protect b-gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in b-gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the b-gal and Neu1 deficiencies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: beta-galactosidase 2; beta-galactosidase protective protein; Carboxypeptidase C; Carboxypeptidase L; carboxypeptidase Y-like kininase; carboxypeptidase-L; Cathepsin A; deamidase; lysosomal carboxypeptidase A; Lysosomal protective protein; PPCA; Protective protein cathepsin A; Protective protein for beta-galactosidase; urinary kininase
Gene Aliases: AU019505; CTSA; GLB2; GSL; NGBE; PPCA; PPGB
UniProt ID: (Human) P10619, (Mouse) P16675
Entrez Gene ID: (Human) 5476, (Mouse) 19025, (Rat) 296370
proteolysis
glycosphingolipid metabolic process
intracellular protein transport
regulation of protein stability
positive regulation of catalytic activity
proteolysis involved in cellular protein catabolic process
chaperone-mediated autophagy
regulation of chaperone-mediated autophagy
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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