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Product Details
BS-2672R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human DPP-I, amino acids 365-463.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cathepsin C, known also as dipeptidyl aminopeptidase I (DPPI), is a tetrameric lysosomal cysteine peptidase belonging to the papain family. Cathepsin C is involved in intracellular protein degradation and the processing of protein precursors, where it participates in cell growth, neuraminidase activation, and platelet factor XIII activation. Cathepsin C is largely related to other lysosomal cysteine proteinases, including cathepsin B, H and L. Enzymatically, Cathepsin C is capable of sequentially removing dipeptides from the amino terminus, and it requires halide ions, namely chloride ions, and thiols for complete enzymatic activity. Protein levels of Cathepsin C are detected in a variety of tissues, and it is most highly expressed in spleen, kidney, cytotoxic lymphocytes and myeloid cells, where it localizes to the secretory granule compartment. Cathepsin C is initially synthesized as a proenzyme that is rapidly processed to generate two distinct chains that function together as the mature form of the enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cathepsin C; Cathepsin J; Dipeptidyl peptidase 1; Dipeptidyl peptidase I; Dipeptidyl transferase; dipeptidyl-peptidase; dipeptidyl-peptidase 1; dipeptidyl-peptidase I; dipeptidylpeptidase 1; DPP-I
Gene Aliases: AI047818; CATC; CPPI; CTSC; DPP-I; DPP1; DPPI; HMS; JP; JPD; PALS; PDON1; PLS
UniProt ID: (Human) P53634, (Mouse) P97821, (Rat) P80067
Entrez Gene ID: (Human) 1075, (Mouse) 13032, (Rat) 25423
cysteine-type endopeptidase activity
serine-type endopeptidase activity
protein binding
cysteine-type peptidase activity
peptidase activator activity involved in apoptotic process
phosphatase binding
chloride ion binding
identical protein binding
protein self-association
chaperone binding
peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
hydrolase activity
T cell mediated cytotoxicity
proteolysis
ER to Golgi vesicle-mediated transport
apoptotic process
immune response
aging
response to organic substance
COPII vesicle coating
proteolysis involved in cellular protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
positive regulation of apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of peptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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