Invitrogen

Cathepsin H/K/L/V Recombinant Rabbit Monoclonal Antibody (JM10-78)

View all (3) Cathepsin H/K/L/V antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-32602

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:100
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JM10-78

Immunogen

Synthetic peptide within Human Cathepsin aa 92-138
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809879

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aleurain; Cat H; Cat K; Cat L; Cathepsin B3; Cathepsin BA; Cathepsin K; Cathepsin L1; Cathepsin L2; cathepsin L2, preproprotein; Cathepsin O; cathepsin O1; Cathepsin O2; Cathepsin U; Cathepsin V; Cathepsin X; CP-2; Cyclic protein 2; furless; Major excreted protein; MEP; minisatellite 10q detected by probe MMS10; N-benzoylarginine-beta-naphthylamide hydrolase; nackt; p39 cysteine proteinase; Pro-cathepsin H; Procathepsin L

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Gene Aliases: 1190035F06Rik; ACC-4; ACC-5; ACC4; ACC5; AI323530; AL022844; CATHL; catK; CATL; CATL2; CPSB; CTS02; CTSH; CTSK; CTSL; CTSL1; CTSL2; CTSO; CTSO1; CTSO2; CTSU; CTSV; fs; MEP; MMS10-Q; Ms10q; nkt; PKND; PYCD; UNQ268/PRO305

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UniProt ID: (Human) P09668, (Human) P43235, (Human) P07711, (Human) O60911, (Rat) P00786, (Mouse) P49935, (Rat) O35186, (Mouse) P55097, (Mouse) P06797, (Rat) P07154

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Entrez Gene ID: (Human) 1512, (Human) 1513, (Human) 1514, (Human) 1515, (Rat) 25425, (Mouse) 13036, (Rat) 29175, (Mouse) 13038, (Mouse) 13039, (Rat) 25697

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Function(s)
endopeptidase activity aminopeptidase activity cysteine-type endopeptidase activity serine-type endopeptidase activity protein binding peptidase activity cysteine-type peptidase activity cysteine-type endopeptidase activator activity involved in apoptotic process HLA-A specific activating MHC class I receptor activity thyroid hormone binding fibronectin binding collagen binding proteoglycan binding histone binding serpin family protein binding cysteine-type carboxypeptidase activity kininogen binding protein complex binding peptide binding peptidase activator activity involved in apoptotic process protein self-association hydrolase activity
Process(es)
metanephros development T cell mediated cytotoxicity adaptive immune response immune response-regulating signaling pathway proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cell proliferation positive regulation of gene expression positive regulation of epithelial cell migration neuropeptide catabolic process bradykinin catabolic process positive regulation of peptidase activity antigen processing and presentation positive regulation of cell migration zymogen activation protein destabilization response to retinoic acid membrane protein proteolysis negative regulation of apoptotic process surfactant homeostasis cellular protein metabolic process positive regulation of angiogenesis proteolysis involved in cellular protein catabolic process dichotomous subdivision of terminal units involved in lung branching ERK1 and ERK2 cascade cellular response to thyroid hormone stimulus positive regulation of apoptotic signaling pathway cell communication negative regulation of keratinocyte proliferation protein processing protein autoprocessing hair follicle morphogenesis catagen decidualization epithelial tube branching involved in lung morphogenesis regulation of actin cytoskeleton reorganization spermatogenesis male gonad development cellular response to starvation response to glucose multicellular organism aging response to organic cyclic compound nerve development collagen catabolic process response to gonadotropin autophagic cell death response to glucocorticoid Sertoli cell differentiation intramembranous ossification bone resorption antigen processing and presentation of exogenous peptide antigen via MHC class II extracellular matrix disassembly toll-like receptor signaling pathway macrophage apoptotic process regulation of mitophagy positive regulation of protein targeting to mitochondrion
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