Proteintech

Cathepsin K Polyclonal Antibody

Cathepsin K Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

Cathepsin K Antibody (11239-1-AP) in ICC/IF

Immunofluorescent analysis of ROS1728 cells using 11239-1-AP (Cathepsin K antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Cathepsin K Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Cathepsin K Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11239-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

View 45 publications 45 publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:20-1:200

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Cathepsin K Fusion Protein Ag1761 (1-329 aa encoded by BC016058)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MWGLKVLLL PVVSFALYPE EILDTHWELW KKTHRKQYNN KVDEISRRLI WEKNLKYISI HNLEASLGVH TYELAMNHLG DMTSEEVVQK MTGLKVPLSH SRSNDTLYIP EWEGRAPDSV DYRKKGYVTP VKNQGQCGSC WAFSSVGALE GQLKKKTGKL LNLSPQNLVD CVSENDGCGG GYMTNAFQYV QKNRGIDSED AYPYVGQEES CMYNPTGKAA KCRGYREIPE GNEKALKRAV ARVGPVSVAI DASLTSFQFY SKGVYYDESC NSDNLNHAVL AVGYGIQKGN KHWIIKNSWG ENWGNKGYIL MARNKNNACG IANLASFPKM (1-329 aa encoded by BC016058)

Target Information

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis.

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Mon Mar 20 00:00:00 UTC 2023

Isopsoralen suppresses receptor activator of nuclear factor kappa-β ligand-induced osteoclastogenesis by inhibiting the NF-κB signaling.

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Effect of mitophagy in the formation of osteomorphs derived from osteoclasts.

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Huang T,Wang Y,Yu Z,Miao X,Jiang Z,Yu K,Fu M,Lai K,Wang Y,Yang G

Fri May 19 00:00:00 UTC 2023

Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation.

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Fri Jun 16 00:00:00 UTC 2023

Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation.

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Mon Oct 24 00:00:00 UTC 2022

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Fri Apr 01 00:00:00 UTC 2022

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Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity in mice.

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Wed Jan 01 00:00:00 UTC 2020

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Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis.

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miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN/PI3K/AKT/FoxO1 pathway.

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SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.

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YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism.

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YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism.

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Tue May 01 00:00:00 UTC 2018

Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.

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Cai C,Liu C,Zhao L,Liu H,Li W,Guan H,Zhao L,Xiao J

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Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.

Frontiers in pharmacology

Cai C,Liu C,Zhao L,Liu H,Li W,Guan H,Zhao L,Xiao J

Wed Sep 30 00:00:00 UTC 2020

Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces Bone Loss in Mice.

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Sui X,Deng S,Liu M,Fan L,Wang Y,Xu H,Sun Y,Kishen A,Zhang Q

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Pulsed electromagnetic field inhibits RANKL-dependent osteoclastic differentiation in RAW264.7 cells through the Ca²⁺-calcineurin-NFATc1 signaling pathway.

Biochemical and biophysical research communications

Zhang J,Xu H,Han Z,Chen P,Yu Q,Lei Y,Li Z,Zhao M,Tian J

Sun Jan 08 00:00:00 UTC 2017

Pulsed electromagnetic field inhibits RANKL-dependent osteoclastic differentiation in RAW264.7 cells through the Ca²⁺-calcineurin-NFATc1 signaling pathway.

Biochemical and biophysical research communications

Zhang J,Xu H,Han Z,Chen P,Yu Q,Lei Y,Li Z,Zhao M,Tian J

Sun Jan 08 00:00:00 UTC 2017

Cathepsin K in Lymphangioleiomyomatosis: LAM Cell-Fibroblast Interactions Enhance Protease Activity by Extracellular Acidification.

The American journal of pathology

Dongre A,Clements D,Fisher AJ,Johnson SR

Tue Aug 01 00:00:00 UTC 2017

Cathepsin K in Lymphangioleiomyomatosis: LAM Cell-Fibroblast Interactions Enhance Protease Activity by Extracellular Acidification.

The American journal of pathology

Dongre A,Clements D,Fisher AJ,Johnson SR

Tue Aug 01 00:00:00 UTC 2017

Role of endoplasmic reticulum stress in disuse osteoporosis.

Bone

Li J,Yang S,Li X,Liu D,Wang Z,Guo J,Tan N,Gao Z,Zhao X,Zhang J,Gou F,Yokota H,Zhang P

Sat Apr 01 00:00:00 UTC 2017

Role of endoplasmic reticulum stress in disuse osteoporosis.

Bone

Li J,Yang S,Li X,Liu D,Wang Z,Guo J,Tan N,Gao Z,Zhao X,Zhang J,Gou F,Yokota H,Zhang P

Sat Apr 01 00:00:00 UTC 2017

Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.

Oncology letters

Sun T,Jiang D,Zhang L,Su Q,Mao W,Jiang C

Fri Jan 01 00:00:00 UTC 2016

Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.

Oncology letters

Sun T,Jiang D,Zhang L,Su Q,Mao W,Jiang C

Fri Jan 01 00:00:00 UTC 2016

Increased expression and activation of cathepsin K in human osteoarthritic cartilage and synovial tissues.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Kozawa E,Cheng XW,Urakawa H,Arai E,Yamada Y,Kitamura S,Sato K,Kuzuya M,Ishiguro N,Nishida Y

Fri Jan 01 00:00:00 UTC 2016

Increased expression and activation of cathepsin K in human osteoarthritic cartilage and synovial tissues.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Kozawa E,Cheng XW,Urakawa H,Arai E,Yamada Y,Kitamura S,Sato K,Kuzuya M,Ishiguro N,Nishida Y

Fri Jan 01 00:00:00 UTC 2016

Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis.

Scientific reports

Li X,Yang J,Liu D,Li J,Niu K,Feng S,Yokota H,Zhang P

Mon Apr 18 00:00:00 UTC 2016

Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis.

Scientific reports

Li X,Yang J,Liu D,Li J,Niu K,Feng S,Yokota H,Zhang P

Mon Apr 18 00:00:00 UTC 2016

Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity.

Scientific reports

Haque M,Song J,Fino K,Sandhu P,Song X,Lei F,Zheng S,Ni B,Fang D,Song J

Fri Feb 05 00:00:00 UTC 2016

Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity.

Scientific reports

Haque M,Song J,Fino K,Sandhu P,Song X,Lei F,Zheng S,Ni B,Fang D,Song J

Fri Feb 05 00:00:00 UTC 2016

Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations.

Journal of dental research

Xue Y,Wang L,Xia D,Li Q,Gao S,Dong M,Cai T,Shi S,He L,Hu K,Mao T,Duan X

Fri May 01 00:00:00 UTC 2015

Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations.

Journal of dental research

Xue Y,Wang L,Xia D,Li Q,Gao S,Dong M,Cai T,Shi S,He L,Hu K,Mao T,Duan X

Fri May 01 00:00:00 UTC 2015

Bone histomorphometry in a long-term hemodialysis patient with hypoparathyroidism and sarcoidosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Sumida K,Ubara Y,Hoshino J,Hayami N,Suwabe T,Hiramatsu R,Hasegawa E,Yamanouchi M,Sawa N,Fujii T,Takaichi K

Wed Apr 01 00:00:00 UTC 2015

Bone histomorphometry in a long-term hemodialysis patient with hypoparathyroidism and sarcoidosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Sumida K,Ubara Y,Hoshino J,Hayami N,Suwabe T,Hiramatsu R,Hasegawa E,Yamanouchi M,Sawa N,Fujii T,Takaichi K

Wed Apr 01 00:00:00 UTC 2015

Hyaluronan inhibits TLR-4 dependent cathepsin K and matrix metalloproteinase 1 expression in human fibroblasts.

Biochemical and biophysical research communications

Hirabara S,Kojima T,Takahashi N,Hanabayashi M,Ishiguro N

Fri Jan 11 00:00:00 UTC 2013

Hyaluronan inhibits TLR-4 dependent cathepsin K and matrix metalloproteinase 1 expression in human fibroblasts.

Biochemical and biophysical research communications

Hirabara S,Kojima T,Takahashi N,Hanabayashi M,Ishiguro N

Fri Jan 11 00:00:00 UTC 2013

Lentiviral small hairpin RNA knockdown of macrophage inflammatory protein-1γ ameliorates experimentally induced osteoarthritis in mice.

Human gene therapy

Shen PC,Lu CS,Shiau AL,Lee CH,Jou IM,Hsieh JL

Tue Oct 01 00:00:00 UTC 2013

Cholesteatoma growth and proliferation: relevance with serpin B3.

The Laryngoscope

Ho KY,Huang HH,Hung KF,Chen JC,Chai CY,Chen WT,Tsai SM,Chien CY,Wang HM,Wu YJ

Sat Dec 01 00:00:00 UTC 2012

Cholesteatoma growth and proliferation: relevance with serpin B3.

The Laryngoscope

Ho KY,Huang HH,Hung KF,Chen JC,Chai CY,Chen WT,Tsai SM,Chien CY,Wang HM,Wu YJ

Sat Dec 01 00:00:00 UTC 2012

Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis.

Arthritis and rheumatism

Kozawa E,Nishida Y,Cheng XW,Urakawa H,Arai E,Futamura N,Shi GP,Kuzuya M,Hu L,Sasaki T,Ishiguro N

Wed Feb 01 00:00:00 UTC 2012

Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis.

Arthritis and rheumatism

Kozawa E,Nishida Y,Cheng XW,Urakawa H,Arai E,Futamura N,Shi GP,Kuzuya M,Hu L,Sasaki T,Ishiguro N

Wed Feb 01 00:00:00 UTC 2012

Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice.

Arthritis and rheumatism

MacLellan LM,Montgomery J,Sugiyama F,Kitson SM,Thümmler K,Silverman GJ,Beers SA,Nibbs RJ,McInnes IB,Goodyear CS

Thu Dec 01 00:00:00 UTC 2011

Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice.

Arthritis and rheumatism

MacLellan LM,Montgomery J,Sugiyama F,Kitson SM,Thümmler K,Silverman GJ,Beers SA,Nibbs RJ,McInnes IB,Goodyear CS

Thu Dec 01 00:00:00 UTC 2011

Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts.

Respiratory research

Zhang D,Huang C,Yang C,Liu RJ,Wang J,Niu J,Brömme D

Tue Nov 29 00:00:00 UTC 2011

Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts.

Respiratory research

Zhang D,Huang C,Yang C,Liu RJ,Wang J,Niu J,Brömme D

Tue Nov 29 00:00:00 UTC 2011

Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts.

Respiratory research

Zhang D,Huang C,Yang C,Liu RJ,Wang J,Niu J,Brömme D

Tue Nov 29 00:00:00 UTC 2011

Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts.

Respiratory research

Zhang D,Huang C,Yang C,Liu RJ,Wang J,Niu J,Brömme D

Tue Nov 29 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: Cat K; Cathepsin K; Cathepsin O; cathepsin O1; Cathepsin O2; Cathepsin X; MGC23107; minisatellite 10q detected by probe MMS10

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Gene Aliases: AI323530; catK; CTS02; CTSK; CTSO; CTSO1; CTSO2; MMS10-Q; Ms10q; PKND; PYCD

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UniProt ID: (Human) P43235, (Rat) O35186, (Mouse) P55097

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Entrez Gene ID: (Human) 1513, (Rat) 29175, (Mouse) 13038

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Function(s)

fibronectin binding cysteine-type endopeptidase activity serine-type endopeptidase activity protein binding collagen binding cysteine-type peptidase activity proteoglycan binding peptidase activity hydrolase activity

Process(es)

intramembranous ossification proteolysis collagen catabolic process bone resorption proteolysis involved in cellular protein catabolic process toll-like receptor signaling pathway extracellular matrix disassembly regulation of mitophagy positive regulation of protein targeting to mitochondrion

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Cathepsin K Polyclonal Antibody

Cathepsin K Antibody (11239-1-AP) in ICC/IF

Product Details

11239-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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