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Product Details
MA5-23928
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
182021
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Cathepsin V Val18-Val334
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2610131
Product Specific Information
In direct ELISAs and Western blots, no cross-reactivity with recombinant human Cathepsin B, C, F, L, O, S, or Z is observed. This antibody specifically identifies the pro form but not the active form of Cathepsin V in Western blots.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Cathepsin V (CTSU, CTSV, CATL2, cathepsin U, cathepsin L2) is a lysosomal cysteine proteinase that influences corneal physiology, and mediates degradation of invariant chain in human thymus. Cathepsin V is present in corneal epithelium, activated macrophages, and colorectal and breast carcinomas. A 1.8-kb mRNA to Cathepsin V is present in normal human thymus and testis. Cathepsin V is a member of the peptidase C1 family. Cysteine proteinases are synthesized as preproenzymes, which are processed to the corresponding proenzymes. The proenzymes are either targeted to the lysosome or continue along the cellular secretory route.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cathepsin L2; cathepsin L2, preproprotein; Cathepsin U; Cathepsin V; PRO305; UNQ268
Gene Aliases: CATL2; CTSL2; CTSU; CTSV; UNQ268/PRO305
UniProt ID: (Human) O60911
Entrez Gene ID: (Human) 1515
spermatogenesis
cellular response to starvation
response to glucose
multicellular organism aging
negative regulation of keratinocyte proliferation
protein autoprocessing
antigen processing and presentation of exogenous peptide antigen via MHC class II
nerve development
extracellular matrix disassembly
hair follicle morphogenesis
response to gonadotropin
decidualization
autophagic cell death
response to glucocorticoid
proteolysis involved in cellular protein catabolic process
Sertoli cell differentiation
regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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