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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Caveolin 1 Antibodies

          Invitrogen

          Caveolin 1 Polyclonal Antibody

          Advanced Verification
          7 Published Figures
          16 References
          View all (47) Caveolin 1 antibodies

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          Datasheet
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          Datasheet
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          Cite Caveolin 1 Polyclonal Antibody

          • Antibody Testing Data (4)
          • Published Figures (7)
          • Advanced Verification (3)
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 14

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          Caveolin 1 Antibody (PA1-064) in ICC/IF

          Immunofluorescence analysis of Caveolin 1 was done on 70% confluent log phase A-375 cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with Caveolin 1 Rabbit Polyclonal Antibody (Product # PA1-064) at 1 µg/mL in 1% BSA and incubated for 3 hours at room tempe... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Immunoprecipitation (IP)
          Caveolin 1 Antibody in Western Blot, Immunocytochemistry, Immunoprecipitation (WB, ICC/IF, IP)
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Caveolin 1 Antibody in Immunohistochemistry (IHC)
          Caveolin 1 Antibody in Immunohistochemistry (IHC)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody
          Caveolin 1 Antibody
          Caveolin 1 Antibody

          Product Details

          PA1-064

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1-2 µg/mL
          View 10 publications 10 publications

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          1-2 µg/mL
          View 4 publications 4 publications

          Immunoprecipitation (IP)

          5 µg
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Dog, Hamster, Human, Mouse, Rat

          Published species

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide corresponding to residues M(1) S G G K Y V D S E G H L Y T V P(17) C of human CAV1.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS with 1mg/mL BSA

          Contains

          0.05% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2072027

          Product Specific Information

          PA1-064 detects caveolin 1 from human, canine, hamster, mouse, and rat tissues and cells.

          PA1-064 has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects an ~22 kDa protein representing caveolin 1 from rat heart protein extract.

          The PA1-064 immunogen is a synthetic peptide corresponding to residues M(1) S G G K Y V D S E G H L Y T V P(17) C of human CAV1. This sequence is completely conserved between human, mouse, canine, bovine, and rat. The PA1-064 immunizing peptide (Cat. # PEP-146) is available for use in neutralization and control experiments.

          Target Information

          Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: caveolae; caveolin 1, caveolae protein, 22kDa; caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa; Caveolin-1; cell growth-inhibiting protein 32; HGNC:1527; OTTHUMP00000196475; Vesicular integral-membrane protein VIP21

          View more View less

          Gene Aliases: BSCL3; CAV; Cav-1; CAV1; caveolin 1; Caveolin-1; CGL3; LCCNS; MSTP085; PPH3; VIP21

          View more View less

          UniProt ID: (Dog) P33724, (Human) Q03135, (Mouse) P49817

          View more View less

          Entrez Gene ID: (Dog) 403980, (Human) 857, (Mouse) 12389, (Rat) 25404, (Chinese hamster) 100753021

          View more View less

          Function(s)
          receptor binding structural molecule activity protein binding peptidase activator activity protein kinase binding protein binding, bridging protein complex scaffold identical protein binding ion channel binding protein heterodimerization activity Rac GTPase binding nitric-oxide synthase binding ATPase binding inward rectifier potassium channel inhibitor activity RNA polymerase I transcription factor binding patched binding cholesterol binding enzyme binding syntaxin binding MDM2/MDM4 family protein binding SNARE binding kinase binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade inactivation of MAPK activity angiogenesis vasculogenesis response to hypoxia negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation negative regulation of cytokine-mediated signaling pathway regulation of the force of heart contraction response to ischemia regulation of the force of heart contraction by chemical signal triglyceride metabolic process calcium ion transport cellular calcium ion homeostasis endocytosis regulation of smooth muscle contraction skeletal muscle tissue development lactation protein localization negative regulation of cell proliferation response to mechanical stimulus positive regulation of signal transduction negative regulation of signal transduction positive regulation of calcium ion transport into cytosol posttranscriptional regulation of gene expression positive regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of peptidase activity receptor-mediated endocytosis of virus by host cell regulation of fatty acid metabolic process lipid storage regulation of blood coagulation negative regulation of BMP signaling pathway negative regulation of epithelial cell differentiation mammary gland development positive regulation of microtubule polymerization T cell costimulation negative regulation of protein ubiquitination positive regulation of protein ubiquitination negative regulation of protein binding positive regulation of protein binding maintenance of protein location in cell response to progesterone negative regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation cholesterol efflux nitric oxide homeostasis positive regulation of toll-like receptor 3 signaling pathway wound healing vasoconstriction negative regulation of tyrosine phosphorylation of Stat5 protein cholesterol homeostasis positive regulation of catalytic activity negative regulation of MAP kinase activity negative regulation of MAPK cascade response to estrogen negative regulation of nitric oxide biosynthetic process negative regulation of neuron differentiation positive regulation of endocytosis positive regulation of vasoconstriction negative regulation of JAK-STAT cascade microtubule polymerization negative regulation of pinocytosis negative regulation of smooth muscle cell proliferation negative regulation of nitric-oxide synthase activity protein oligomerization protein homooligomerization regulation of cytosolic calcium ion concentration response to calcium ion membrane depolarization regulation of peptidase activity calcium ion homeostasis mammary gland involution positive regulation of cell adhesion molecule production negative regulation of protein tyrosine kinase activity negative regulation of ERK1 and ERK2 cascade caveola assembly cellular response to mechanical stimulus cellular response to exogenous dsRNA cellular response to peptide hormone stimulus cellular response to hyperoxia cellular response to transforming growth factor beta stimulus caveolin-mediated endocytosis regulation of heart rate by cardiac conduction angiotensin-activated signaling pathway involved in heart process negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway cellular senescence apoptotic signaling pathway regulation of membrane repolarization during action potential regulation of ventricular cardiac muscle cell action potential negative regulation of peptidyl-tyrosine autophosphorylation negative regulation of potassium ion transmembrane transport regulation of cell communication by electrical coupling involved in cardiac conduction regulation of inward rectifier potassium channel activity positive regulation of gap junction assembly receptor internalization involved in canonical Wnt signaling pathway negative regulation of anoikis positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway negative regulation of cation channel activity biological_process cellular response to starvation response to bacterium vesicle organization negative regulation of transforming growth factor beta receptor signaling pathway receptor internalization protein localization to plasma membrane raft negative regulation of necroptotic process regulation of ruffle assembly protein localization to basolateral plasma membrane regulation of entry of bacterium into host cell response to nutrient response to gamma radiation cholesterol transport organ regeneration response to drug leukocyte migration regulation of nitric-oxide synthase activity response to glucocorticoid regulation of cardiac muscle cell action potential involved in regulation of contraction positive regulation of ER-associated ubiquitin-dependent protein catabolic process beta-catenin destruction complex disassembly
          It has to be done as per old AB suggested Products section.
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