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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Caveolin 1 Antibodies

          Invitrogen

          Caveolin 1 Polyclonal Antibody

          Advanced Verification
          4 Published Figures
          9 References
          View all (47) Caveolin 1 antibodies

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          Datasheet
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          Datasheet
          Protocols
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          Cite Caveolin 1 Polyclonal Antibody

          • Antibody Testing Data (10)
          • Published Figures (4)
          • Advanced Verification (3)
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 17

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          Caveolin 1 Antibody (PA5-17447) in ICC/IF

          Immunofluorescence analysis of Caveolin 1 was performed using 70% confluent log phase HeLa cells treated with 2 nM of Paclitaxel for 24 hr. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Caveolin 1 Rabbit Polyclonal Antibody(Product # PA5-17447) at 1:100 di... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot, Immunoprecipitation (WB, IP)
          Caveolin 1 Antibody in Immunohistochemistry (IHC)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody
          Caveolin 1 Antibody
          Caveolin 1 Antibody

          Product Details

          PA5-17447

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000
          View 2 publications 2 publications

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          1:250
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          1:400
          View 3 publications 3 publications

          Flow Cytometry (Flow)

          1:50
          -

          Immunoprecipitation (IP)

          1:50
          View 1 publication 1 publication

          Miscellaneous PubMed (MISC)

          -
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Bovine, Chicken, Hamster, Human, Mouse, Pig, Rat, Zebrafish

          Published species

          Dog, Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide corresponding to residues surrounding Glu20 of human caveolin-1
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          33 µg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_10985023

          Product Specific Information

          It is not recommended to aliquot this antibody.

          This antibody is not cross-reactive with caveolin-2 or -3.

          Target Information

          Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: caveolae; caveolin 1, caveolae protein, 22kDa; caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa; Caveolin-1; cell growth-inhibiting protein 32; HGNC:1527; OTTHUMP00000196475; variant a; variant b

          View more View less

          Gene Aliases: BOS_4208; BSCL3; CAV; Cav-1; CAV1; Caveolin-1; CGL3; LCCNS; MSTP085; PPH3; VIP21; wu:fc07c04

          View more View less

          UniProt ID: (Pig) Q6RVA9, (Chicken) P35431, (Bovine) P79132, (Human) Q03135, (Mouse) P49817

          View more View less

          Entrez Gene ID: (Pig) 404693, (Chicken) 373996, (Bovine) 281040, (Human) 857, (Mouse) 12389, (Rat) 25404, (Chinese hamster) 100753021, (Zebrafish) 323695

          View more View less

          Function(s)
          patched binding structural molecule activity peptidase activator activity nitric-oxide synthase binding RNA polymerase I transcription factor binding receptor binding protein binding cholesterol binding enzyme binding protein kinase binding syntaxin binding protein binding, bridging protein complex scaffold identical protein binding ion channel binding protein heterodimerization activity Rac GTPase binding ATPase binding inward rectifier potassium channel inhibitor activity MDM2/MDM4 family protein binding SNARE binding kinase binding beta-catenin binding
          Process(es)
          somitogenesis heart development dorsal/ventral pattern formation cell differentiation intestinal cholesterol absorption neuromast development regulation of defense response to virus notochord cell vacuolation cardiac muscle cell proliferation regulation of type I interferon-mediated signaling pathway cardiac muscle tissue regeneration caveola assembly T cell costimulation negative regulation of transcription from RNA polymerase II promoter MAPK cascade inactivation of MAPK activity angiogenesis vasculogenesis response to hypoxia negative regulation of endothelial cell proliferation negative regulation of cytokine-mediated signaling pathway response to ischemia regulation of the force of heart contraction by chemical signal triglyceride metabolic process calcium ion transport regulation of smooth muscle contraction skeletal muscle tissue development lactation protein localization biological_process cellular response to starvation positive regulation of calcium ion transport into cytosol vesicle organization regulation of fatty acid metabolic process lipid storage regulation of blood coagulation negative regulation of BMP signaling pathway negative regulation of epithelial cell differentiation negative regulation of protein binding response to progesterone negative regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation nitric oxide homeostasis vasoconstriction negative regulation of tyrosine phosphorylation of Stat5 protein cholesterol homeostasis positive regulation of catalytic activity response to estrogen negative regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction negative regulation of nitric-oxide synthase activity protein homooligomerization regulation of cytosolic calcium ion concentration response to calcium ion membrane depolarization mammary gland involution cellular response to hyperoxia caveolin-mediated endocytosis negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway apoptotic signaling pathway receptor internalization involved in canonical Wnt signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway positive regulation of endothelial cell proliferation regulation of the force of heart contraction cellular calcium ion homeostasis endocytosis negative regulation of cell proliferation response to mechanical stimulus positive regulation of signal transduction negative regulation of signal transduction posttranscriptional regulation of gene expression positive regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of peptidase activity receptor-mediated endocytosis of virus by host cell mammary gland development positive regulation of microtubule polymerization negative regulation of protein ubiquitination positive regulation of protein ubiquitination positive regulation of protein binding maintenance of protein location in cell cholesterol efflux positive regulation of toll-like receptor 3 signaling pathway wound healing negative regulation of MAP kinase activity negative regulation of MAPK cascade negative regulation of neuron differentiation positive regulation of endocytosis negative regulation of JAK-STAT cascade microtubule polymerization negative regulation of pinocytosis negative regulation of smooth muscle cell proliferation protein oligomerization regulation of peptidase activity calcium ion homeostasis positive regulation of cell adhesion molecule production negative regulation of protein tyrosine kinase activity negative regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to exogenous dsRNA cellular response to peptide hormone stimulus cellular response to transforming growth factor beta stimulus regulation of heart rate by cardiac conduction angiotensin-activated signaling pathway involved in heart process cellular senescence regulation of membrane repolarization during action potential regulation of ventricular cardiac muscle cell action potential negative regulation of peptidyl-tyrosine autophosphorylation negative regulation of potassium ion transmembrane transport regulation of cell communication by electrical coupling involved in cardiac conduction regulation of inward rectifier potassium channel activity positive regulation of gap junction assembly negative regulation of anoikis negative regulation of cation channel activity response to nutrient response to bacterium response to gamma radiation cholesterol transport negative regulation of transforming growth factor beta receptor signaling pathway organ regeneration receptor internalization response to drug protein localization to plasma membrane raft leukocyte migration regulation of nitric-oxide synthase activity response to glucocorticoid negative regulation of necroptotic process regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of ruffle assembly positive regulation of ER-associated ubiquitin-dependent protein catabolic process protein localization to basolateral plasma membrane beta-catenin destruction complex disassembly regulation of entry of bacterium into host cell
          It has to be done as per old AB suggested Products section.
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