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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Caveolin 1 Antibodies

          Invitrogen

          Caveolin 1 Polyclonal Antibody

          View all (47) Caveolin 1 antibodies

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          Cite Caveolin 1 Polyclonal Antibody

          • Antibody Testing Data (2)
          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          Caveolin 1 Antibody (PA5-32691) in IHC (P)

          Immunohistochemistry analysis of Caveolin 1 in Human Brain, Cortex. Samples were incubated with Caveolin 1 polyclonal antibody (Product # PA5-32691). formalin-fixed paraffin-embedded . {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Product Details

          PA5-32691

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:100
          -
          Product Specifications

          Species Reactivity

          Dog, Guinea pig, Human, Non-human primate

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic 16 amino acid peptide from N-terminus of human CAV1 / Caveolin.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS

          Contains

          0.1% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2550154

          Product Specific Information

          Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Dog, Guinea pig (100%); Galago, Mouse, Rat, Ferret, Sheep, Bovine, Cat, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Pig, Armadillo (94%); Opossum, Platypus (88%); Turkey, Chicken (81%).

          For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

          Target Information

          Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: caveolae; caveolin 1, caveolae protein, 22kDa; Caveolin-1; cell growth-inhibiting protein 32; HGNC:1527; OTTHUMP00000196475; Vesicular integral-membrane protein VIP21

          View more View less

          Gene Aliases: BSCL3; CAV; CAV1; caveolin 1; CGL3; LCCNS; MSTP085; PPH3; VIP21

          View more View less

          UniProt ID: (Dog) P33724, (Human) Q03135

          View more View less

          Entrez Gene ID: (Dog) 403980, (Human) 857

          View more View less

          Function(s)
          receptor binding structural molecule activity protein binding peptidase activator activity protein kinase binding protein binding, bridging protein complex scaffold identical protein binding ion channel binding protein heterodimerization activity Rac GTPase binding nitric-oxide synthase binding ATPase binding inward rectifier potassium channel inhibitor activity RNA polymerase I transcription factor binding patched binding cholesterol binding enzyme binding syntaxin binding MDM2/MDM4 family protein binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade inactivation of MAPK activity angiogenesis vasculogenesis response to hypoxia negative regulation of endothelial cell proliferation negative regulation of cytokine-mediated signaling pathway response to ischemia regulation of the force of heart contraction by chemical signal triglyceride metabolic process calcium ion transport regulation of smooth muscle contraction skeletal muscle tissue development lactation biological_process cellular response to starvation response to bacterium positive regulation of calcium ion transport into cytosol posttranscriptional regulation of gene expression positive regulation of gene expression positive regulation of peptidase activity vesicle organization receptor-mediated endocytosis of virus by host cell regulation of fatty acid metabolic process lipid storage regulation of blood coagulation negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway negative regulation of epithelial cell differentiation T cell costimulation negative regulation of protein ubiquitination positive regulation of protein ubiquitination receptor internalization negative regulation of protein binding positive regulation of protein binding response to progesterone negative regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation nitric oxide homeostasis positive regulation of toll-like receptor 3 signaling pathway vasoconstriction negative regulation of tyrosine phosphorylation of Stat5 protein cholesterol homeostasis positive regulation of catalytic activity response to estrogen protein localization to plasma membrane raft negative regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction negative regulation of pinocytosis negative regulation of nitric-oxide synthase activity protein homooligomerization regulation of cytosolic calcium ion concentration response to calcium ion membrane depolarization mammary gland involution positive regulation of cell adhesion molecule production negative regulation of necroptotic process negative regulation of protein tyrosine kinase activity caveola assembly cellular response to exogenous dsRNA cellular response to peptide hormone stimulus cellular response to hyperoxia cellular response to transforming growth factor beta stimulus caveolin-mediated endocytosis regulation of heart rate by cardiac conduction angiotensin-activated signaling pathway involved in heart process negative regulation of canonical Wnt signaling pathway apoptotic signaling pathway regulation of membrane repolarization during action potential regulation of ventricular cardiac muscle cell action potential regulation of ruffle assembly negative regulation of peptidyl-tyrosine autophosphorylation negative regulation of potassium ion transmembrane transport regulation of cell communication by electrical coupling involved in cardiac conduction regulation of inward rectifier potassium channel activity protein localization to basolateral plasma membrane positive regulation of gap junction assembly receptor internalization involved in canonical Wnt signaling pathway regulation of entry of bacterium into host cell negative regulation of anoikis positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway positive regulation of endothelial cell proliferation cellular calcium ion homeostasis response to nutrient protein localization response to gamma radiation negative regulation of muscle cell apoptotic process cholesterol transport mammary gland development organ regeneration positive regulation of microtubule polymerization maintenance of protein location in cell cholesterol efflux wound healing response to drug negative regulation of MAPK cascade negative regulation of neuron differentiation positive regulation of endocytosis negative regulation of JAK-STAT cascade microtubule polymerization negative regulation of smooth muscle cell proliferation leukocyte migration regulation of nitric-oxide synthase activity response to glucocorticoid regulation of peptidase activity calcium ion homeostasis negative regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus positive regulation of canonical Wnt signaling pathway cellular senescence regulation of cardiac muscle cell action potential involved in regulation of contraction positive regulation of ER-associated ubiquitin-dependent protein catabolic process beta-catenin destruction complex disassembly negative regulation of cation channel activity
          It has to be done as per old AB suggested Products section.
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