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Invitrogen
Caveolin 2 Monoclonal Antibody (ZC013)
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FIGURE: 1 / 5
Caveolin 2 Antibody (41-0700) in WB
Western blot was performed using Caveolin 2 Monoclonal Antibody (ZC013) (Product # 41-0700) and a~18 kDa band corresponding to Caveolin-2 was observed in A431, A549, and HeLa; and was absent in Jurkat and 3T3L1. Whole cell extracts (30 µg lysate) of A431 (Lane 1), A549 (Lane 2), HeLa (Lane 3), Jurkat (Lane 4) and 3T3L1 (Lane 5) were electrophoresed using NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB... View More
Product Details
41-0700
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
ZC013
Immunogen
Synthetic peptide derived from the C-terminal region of the human caveolin-2 protein
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2533493
Target Information
Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: caveolae; caveolae protein, 20-kD; caveolin 2 isoform a and b; Caveolin-2; MGC12294; Phospho-CAV2
Gene Aliases: CAV; CAV2
UniProt ID: (Human) P51636
Entrez Gene ID: (Human) 858
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
vesicle fusion
mitochondrion organization
endoplasmic reticulum organization
regulation of mitotic nuclear division
insulin receptor signaling pathway
vesicle organization
receptor-mediated endocytosis of virus by host cell
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of MAPK cascade
positive regulation of GTPase activity
positive regulation by host of viral release from host cell
positive regulation by host of viral process
vesicle docking
skeletal muscle fiber development
protein oligomerization
positive regulation of dopamine receptor signaling pathway
caveola assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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