Invitrogen

Caveolin 3 Polyclonal Antibody

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10 Published Figures
9 References
View all (12) Caveolin 3 antibodies

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Datasheet
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Questions & Answers

Product Details

PA1-066

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:200
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
View 6 publications 6 publications

Immunoprecipitation (IP)

5 µg
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues M(1) M T E E H T D L E A R I I K D I H C(19) C of mouse CAV3
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2072446

Product Specific Information

PA1-066 detects Caveolin 3 from rat and mouse tissues. This antibody does not detect caveolin-1 or -2.

PA1-066 has been successfully used in Western blot, IF, immunocytochemistry and immunoprecipitation procedures. By Western blot, this antibody detects an ~21 kDa protein representing Caveolin 3 from rat heart homogenate.

The PA1-066 immunogen is a synthetic peptide corresponding to residues M(1) M T E E H T D L E A R I I K D I H C(19) C of mouse CAV3. This sequence is ~85% conserved in human Caveolin 3. PA1-066 immunizing peptide (Cat. # PEP-081) is available for use in neutralization and control experiments.

Target Information

Caveolin-3 (CAV3) acts as a scaffolding protein within the caveolar membrane. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-3 may also regulate voltage-gated potassium channels. It also plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Caveolin-3 also mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. Mutations in the gene can result in HyperCKmia, rippling muscle disease 2, cardiomyopathy, long QT syndrome 9, sudden infant death syndrome, and myopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CAV; Caveolin-3; M-caveolin; MGC126100; MGC126101; MGC126129

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Gene Aliases: AI385751; Cav-3; CAV3; LGMD1C; LQT9; M-cav; VIP-21; VIP21

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UniProt ID: (Human) P56539, (Rat) P51638, (Mouse) P51637

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Entrez Gene ID: (Human) 859, (Rat) 29161, (Mouse) 12391

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Function(s)
calcium channel regulator activity protein binding protein C-terminus binding sodium channel regulator activity potassium channel inhibitor activity protein complex binding protein complex scaffold alpha-tubulin binding ion channel binding nitric-oxide synthase binding connexin binding enzyme binding
Process(es)
plasma membrane repair regulation of heart rate negative regulation of protein kinase activity triglyceride metabolic process endocytosis muscle contraction plasma membrane organization actin filament organization positive regulation of cytosolic calcium ion concentration muscle organ development myoblast fusion regulation of heart contraction protein localization positive regulation of cell proliferation negative regulation of cardiac muscle hypertrophy positive regulation of myotube differentiation regulation of skeletal muscle contraction cell growth regulation of transforming growth factor beta receptor signaling pathway cell differentiation positive regulation of microtubule polymerization cytoplasmic microtubule organization membrane raft organization T-tubule organization detection of muscle stretch regulation of signal transduction by receptor internalization regulation of membrane potential glucose homeostasis cholesterol homeostasis negative regulation of MAP kinase activity negative regulation of MAPK cascade negative regulation of cell size muscle cell cellular homeostasis negative regulation of nitric-oxide synthase activity regulation of nerve growth factor receptor activity nucleus localization regulation of protein kinase B signaling negative regulation of calcium ion transport cardiac muscle cell development regulation of cardiac muscle contraction negative regulation of sarcomere organization regulation of ventricular cardiac muscle cell membrane repolarization heart trabecula formation regulation of ventricular cardiac muscle cell membrane depolarization regulation of branching involved in mammary gland duct morphogenesis negative regulation of cell growth involved in cardiac muscle cell development caveola assembly protein localization to plasma membrane ventricular cardiac muscle cell action potential establishment of protein localization to plasma membrane regulation of calcium ion import regulation of p38MAPK cascade regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of potassium ion transmembrane transporter activity regulation of calcium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transport negative regulation of protein localization to cell surface positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of sodium ion transmembrane transporter activity positive regulation of caveolin-mediated endocytosis myotube differentiation regulation of calcium ion transport
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