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Proteintech
Cd2ap Polyclonal Antibody
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Product Details
24122-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cd2ap Fusion Protein Ag21170 (1-637 aa encoded by BC157901)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MVDYIVEYD YDAVHDDELT IRVGEIIRNV KKLQEEGWLE GELNGRRGMF PDNFVKEIKR ETEPKDDNLP IKRERQGNVA SLVQRISTYG LPAGGIQPHP QTKAIKKKTK KRQCKVLFDY SPQNEDELEL IVGDVIDVIE EVEEGWWSGT LNNKLGLFPS NFVKELESTE DGETHNAQEE SEVPLTGPTS PLPSPGNGSE PAPGSVAQPK KIRGIGFGDI FKEGSVKLRT RTSSSETEEK KTEKPLILQP LGSRTQNVEV TKPDVDGKIK AKEYCRTLFP YTGTNEDELT FREGEIIHLI SKETGEAGWW KGELNGKEGV FPDNFAVQIS ELDKDFPKPK KPPPPAKGPA PKPDLSAAEK KAFPLKAEEK DEKSLLEQKP SKPAAPQVPP KKPTAPTKAS NLLRSPGAVY PKRPEKPVPP PPPAAKINGE VSIISSKIDT EPVSKPKLDP EQLPVRPKSV DLDAFVARNS KETDDVNFDD IASSENLLHL TANRPKMPGR RLPGRFNGGH SPTQSPEKTL KLPKEDDSGN LKPLEFKKDA SYSSKPSLST PSSASKVNTA AFLTPLELKA KAEADDGKKN SVDELRAQII ELLCIVDALK KDHGKELEKL RKELEEEKAM RSNLEVEIAK LKKAVLLS (1-637 aa encoded by BC157901)
Target Information
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adapter protein CMS; Cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein
Gene Aliases: CD2AP; CMS
UniProt ID: (Human) Q9Y5K6
Entrez Gene ID: (Human) 23607
protein complex assembly
substrate-dependent cell migration, cell extension
cytoskeleton organization
mitotic nuclear division
signal transduction
vesicle organization
single organismal cell-cell adhesion
negative regulation of transforming growth factor beta1 production
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of receptor-mediated endocytosis
cell division
positive regulation of protein localization to nucleus
regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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