Proteintech

Cd31 Polyclonal Antibody

Cd31 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Cd31 Antibody (28083-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 28083-1-AP (Cd31 antibody) at dilution of 1:1000 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

28083-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000

Immunocytochemistry (ICC/IF)

View 8 publications 8 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Pecam1 Fusion Protein Ag27828

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

267 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.

bioRxiv : the preprint server for biology

Kumar R,Vitvitsky V,Seth P,Hiraki HL,Bell H,Andren A,Singhal R,Baker BM,Lyssiotis CA,Shah YM,Banerjee R

Wed Mar 15 00:00:00 UTC 2023

Sufentanil combined with parecoxib sodium inhibits proliferation and metastasis of HER2-positive breast cancer cells and regulates epithelial-mesenchymal transition.

Clinical & experimental metastasis

Xu S,Li X,Li W,Ma N,Ma H,Cui J,You X,Chen X

Sat Apr 01 00:00:00 UTC 2023

Weakly acidic microenvironment of the wound bed boosting the efficacy of acidic fibroblast growth factor to promote skin regeneration.

Frontiers in bioengineering and biotechnology

Pan Q,Fan R,Chen R,Yuan J,Chen S,Cheng B

Tue Mar 21 00:00:00 UTC 2023

High glucose-induced IL-7/IL-7R upregulation of dermal fibroblasts inhibits angiogenesis in a paracrine way in delayed diabetic wound healing.

Journal of cell communication and signaling

Gao R,Zhou P,Li Y,Li Q

Fri Sep 01 00:00:00 UTC 2023

Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions.

Cellular & molecular biology letters

Adzraku SY,Wang G,Cao C,Bao Y,Wang Y,Smith AO,Du Y,Wang H,Li Y,Xu K,Qiao J,Ju W,Zeng L

Mon Jan 16 00:00:00 UTC 2023

Tanshinone IIA enhances the therapeutic efficacy of mesenchymal stem cells derived exosomes in myocardial ischemia/reperfusion injury via up-regulating miR-223-5p.

Journal of controlled release : official journal of the Controlled Release Society

Li S,Yang K,Cao W,Guo R,Liu Z,Zhang J,Fan A,Huang Y,Ma C,Li L,Fan G

Thu Jun 01 00:00:00 UTC 2023

Selenium supplementation enhanced the expression of selenoproteins in hippocampus and played a neuroprotective role in LPS-induced neuroinflammation.

International journal of biological macromolecules

Liang X,Xue Z,Zheng Y,Li S,Zhou L,Cao L,Zou Y

Sat Apr 15 00:00:00 UTC 2023

Selenium supplementation enhanced the expression of selenoproteins in hippocampus and played a neuroprotective role in LPS-induced neuroinflammation.

International journal of biological macromolecules

Liang X,Xue Z,Zheng Y,Li S,Zhou L,Cao L,Zou Y

Sat Apr 15 00:00:00 UTC 2023

FTO-dependent m⁶A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Nature communications

Li B,Xi W,Bai Y,Liu X,Zhang Y,Li L,Bian L,Liu C,Tang Y,Shen L,Yang L,Gu X,Xie J,Zhou Z,Wang Y,Yu X,Wang J,Chao J,Han B,Yao H

Mon Jan 30 00:00:00 UTC 2023

Type 1 diabetes mellitus leads to gingivitis and an early compensatory increase in bone remodeling.

Journal of periodontology

Yuan X,Amin V,Zhu T,Kittaka M,Ueki Y,Bellido TM,Turkkahraman H

Wed Feb 01 00:00:00 UTC 2023

APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading.

The Journal of clinical investigation

Wang C,Nambiar A,Strickland MR,Lee C,Parhizkar S,Moore AC,Musiek ES,Ulrich JD,Holtzman DM

Mon Jul 17 00:00:00 UTC 2023

LncRNA H19 mediates BMP9-induced angiogenesis in mesenchymal stem cells by promoting the p53-Notch1 angiogenic signaling axis.

Genes & diseases

Du C,Cheng Q,Zhao P,Wang C,Zhu Z,Wu X,Gao S,Chen B,Zou J,Huang W,Liao J

Mon May 01 00:00:00 UTC 2023

Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching.

The Journal of biological chemistry

Wei W,Tang X,Jiang N,Ni C,He H,Sun S,Yu M,Yu C,Qiu M,Yan D,Zhou Z,Song Y,Liu H,Zhao B,Lin X

Sat Oct 01 00:00:00 UTC 2022

Investigating the Adipogenic Effects of Different Tissue-Derived Decellularized Matrices.

Frontiers in bioengineering and biotechnology

Tang W,Qi J,Wang Q,Qu Y,Fu S,Luan J

Sat Jul 16 00:00:00 UTC 2022

Role of GADD45A in myocardial ischemia/reperfusion through mediation of the JNK/p38 MAPK and STAT3/VEGF pathways.

International journal of molecular medicine

Wang Y,Gao H,Cao X,Li Z,Kuang Y,Ji Y,Li Y

Thu Dec 01 00:00:00 UTC 2022

Comparative Transcriptome Analyses of Geriatric Rats Associate Age-Related Erectile Dysfunction With a lncRNA-miRNA-mRNA Regulatory Network.

Frontiers in endocrinology

Zhou X,Cong R,Yao L,Zhou X,Luan J,Zhang Q,Zhang X,Ren X,Zhang T,Meng X,Song N

Fri Jul 29 00:00:00 UTC 2022

Exosomal miR-455-3p from BMMSCs prevents cardiac ischemia-reperfusion injury.

Human & experimental toxicology

Wang Y,Shen Y

Wed May 18 00:00:00 UTC 2022

A multifunctional black phosphorus-based adhesive patch intrinsically induces partial EMT for effective burn wound healing.

Biomaterials science

Wang X,Tang X,Li N,Sun Y,Yu R,Zhang J,Li D,Yang B,Sun H

Tue Dec 20 00:00:00 UTC 2022

Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma.

Nature communications

Zhang S,Li Y,Sun S,Liu L,Mu X,Liu S,Jiao M,Chen X,Chen K,Ma H,Li T,Liu X,Wang H,Zhang J,Yang J,Zhang XD

Fri Aug 12 00:00:00 UTC 2022

Hypoxia-Induced LncRNA-MIR210HG Promotes Cancer Progression By Inhibiting HIF-1α Degradation in Ovarian Cancer.

Frontiers in oncology

Liu P,Huang H,Qi X,Bian C,Cheng M,Liu L,Xue L,Zhao X,Yi T,Quan Y

Wed Dec 15 00:00:00 UTC 2021

"γδT Cell-IL17A-Neutrophil" Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy.

Frontiers in immunology

Zhang Z,Yang C,Li L,Zhu Y,Su K,Zhai L,Wang Z,Huang J

Mon Dec 13 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: CD31; CD31 antigen; EndoCAM; GPIIA'; PECA1; PECAM-1; Platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule 1

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Gene Aliases: C85791; CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1; Pecam; PECAM-1; PECAM1

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UniProt ID: (Human) P16284, (Mouse) Q08481

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Entrez Gene ID: (Human) 5175, (Mouse) 18613

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Function(s)

protein binding

Process(es)

platelet degranulation phagocytosis cell adhesion signal transduction cell recognition extracellular matrix organization leukocyte migration diapedesis glomerular endothelium development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Cd31 Polyclonal Antibody

Cd31 Antibody (28083-1-AP) in IHC (P)

Product Details

28083-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Not applicable (N/A)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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