Invitrogen

Cdc42 Recombinant Rabbit Monoclonal Antibody (JJ086-04)

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Datasheet
Protocols
Questions & Answers

Product Details

MA5-32472

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JJ086-04

Immunogen

Recombinant protein within Human CDC42 aa 30-191
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809749

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Rac1 is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for the Rac1 gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein); cell division cycle 42 homolog; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); G25K GTP-binding protein; growth-regulating protein; GTP binding protein, 25kDa; GTP-binding protein; RP1-224A6.5; small GTP binding protein CDC42

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Gene Aliases: AI747189; AU018915; CDC42; CDC42Hs; G25K; TKS

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UniProt ID: (Human) P60953, (Rat) Q8CFN2, (Mouse) P60766

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Entrez Gene ID: (Human) 998, (Rat) 64465, (Mouse) 12540

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Function(s)
GTPase activity protein binding GTP binding protein kinase binding GTP-dependent protein binding mitogen-activated protein kinase kinase kinase binding thioesterase binding apolipoprotein A-I receptor binding identical protein binding Rho GDP-dissociation inhibitor binding ubiquitin protein ligase activity nucleotide binding
Process(es)
positive regulation of protein phosphorylation sprouting angiogenesis cardiac conduction system development keratinocyte development endocytosis actin filament organization Golgi organization regulation of mitotic nuclear division nuclear migration small GTPase mediated signal transduction metabolic process response to glucose positive regulation of gene expression negative regulation of gene expression single organismal cell-cell adhesion regulation of exocytosis substantia nigra development establishment of cell polarity actin cytoskeleton organization hair follicle morphogenesis positive regulation of pseudopodium assembly negative regulation of protein complex assembly keratinization regulation of protein stability positive regulation of cytokinesis positive regulation of peptidyl-serine phosphorylation adherens junction organization cellular protein localization establishment or maintenance of apical/basal cell polarity multicellular organism growth dendritic cell migration regulation of protein catabolic process positive regulation of catalytic activity positive regulation of MAPK cascade regulation of protein heterodimerization activity positive regulation of neuron apoptotic process positive regulation of phosphatidylinositol 3-kinase activity positive regulation of DNA replication regulation of protein kinase activity positive regulation of JNK cascade filopodium assembly neuron fate determination epidermis morphogenesis actin filament bundle assembly regulation of protein metabolic process regulation of filopodium assembly nucleus localization establishment of Golgi localization positive regulation of synapse structural plasticity regulation of attachment of spindle microtubules to kinetochore heart contraction canonical Wnt signaling pathway submandibular salivary gland formation epithelial-mesenchymal cell signaling hair follicle placode formation positive regulation of hair follicle cell proliferation organelle transport along microtubule actin filament branching epithelial cell-cell adhesion positive regulation of intracellular protein transport positive regulation of substrate adhesion-dependent cell spreading establishment or maintenance of cell polarity blood coagulation protein ubiquitination macrophage differentiation positive regulation of cell growth T cell costimulation Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of epidermal growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway regulation of small GTPase mediated signal transduction positive regulation of muscle cell differentiation Wnt signaling pathway, planar cell polarity pathway positive regulation of epithelial cell proliferation involved in lung morphogenesis Rho protein signal transduction nervous system development endosomal transport cell differentiation
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