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Invitrogen
ChREBP Polyclonal Antibody, HRP
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FIGURE: 1 / 3
ChREBP Antibody (PA5-22924) in WB
Diabetes 2015 -
Figure 6 ChREBPbeta depletion attenuates glucose-stimulated beta-cell proliferation in INS-1-derived 832/13 cells. A : INS-1-derived 832/13 cells were treated with control siRNAs (siCon) or siRNAs targeted against ChREBPbeta mRNA (Sibeta-01 and -02) and 24 h later cultured for 16 h in 2 or 20 mmol/L glucose. Immunoblotting was performed using antibodies against ChREBP (ChREBPalpha is visualized) and beta-ac... View More
Product Details
PA5-22924
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An C-terminal synthetic peptide made to the human ChREBP protein sequence (between residues 800-852).
Conjugate
Form
Liquid
Concentration
0.64 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153460
Product Specific Information
The target sequence has 83% sequence homology with mouse ChREBP.
Target Information
ChREBP is a transcription factor involved in activating genes that encode enzymes of fatty acid biosynthesis in liver and adipose. This protein may have relevance to lipid metabolism, obesity, and type II diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bHLHd14; carbohydrate response element binding protein; Carbohydrate-responsive element-binding protein; ChREBP; Class D basic helix-loop-helix protein 14; MLX interacting protein-like; MLX interacting protein-like beta; MLX interactor; MLX-interacting protein-like; putative hepatic transcription factor; Williams Beuren syndrome chromosome region 14; Williams-Beuren syndrome chromosomal region 14 protein; Williams-Beuren syndrome chromosomal region 14 protein homolog; Williams-Beuren syndrome chromosome region 14 homolog; Williams-Beuren syndrome chromosome region 14 protein 1; Williams-Beuren syndrome chromosome region 14 protein 2; Williams-Beuren syndrome chromosome region 14 protein 3; WS basic-helix-loop-helix leucine zipper protein; WS-bHLH
Gene Aliases: BHLHD14; CHREBP; MIO; MLXIPL; MONDOB; WBSCR14; WS-bHLH
UniProt ID: (Human) Q9NP71, (Mouse) Q99MZ3, (Rat) Q8VIP2
Entrez Gene ID: (Human) 51085, (Mouse) 58805, (Rat) 171078
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
carbohydrate response element binding
protein homodimerization activity
protein heterodimerization activity
protein binding
protein kinase binding
sequence-specific DNA binding
protein dimerization activity
negative regulation of transcription from RNA polymerase II promoter
regulation of glycolytic process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
response to glucose
glucose mediated signaling pathway
negative regulation of peptidyl-serine phosphorylation
glucose homeostasis
positive regulation of fatty acid biosynthetic process
positive regulation of glycolytic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of lipid biosynthetic process
fatty acid homeostasis
negative regulation of cell cycle arrest
cellular response to carbohydrate stimulus
cellular response to glucose stimulus
negative regulation of oxidative phosphorylation
regulation of energy homeostasis
anatomical structure morphogenesis
intracellular signal transduction
triglyceride homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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