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Chemerin Polyclonal Antibody

Chemerin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Chemerin Antibody (10216-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta tissue slide using 10216-1-AP (Chemerin antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

10216-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Chemerin Fusion Protein Ag0261 (1-163 aa encoded by BC000069)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRRLLIPLA LWLGAVGVGV AELTEAQRRG LQVALEEFHK HPPVQWAFQE TSVESAVDTP FPAGIFVRLE FKLQQTSCRK RDWKKPECKV RPNGRKRKCL ACIKLGSEDK VLGRLVHCPI ETQVLREAEE HQETQCLRVQ RAGEDPHSFY FPGQFAFSKA LPRS (1-163 aa encoded by BC000069)

Target Information

Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs). Tazarotene-induced gene (TIG) proteins, also designated retinoic acid receptor responder proteins or RAR-responsive proteins, can be membrane bound or secreted. TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles and endothelial cells as well as in pancreas, spleen and intestine. TIGs are activated by tazarotene and have been implicated as growth regulators that mediate the growth suppressive effects of retinoids. TIG2 is a secreted protein that is mainly expressed in epidermis, hair follicles and endothelial cells. TIG2 is inhibited in psoriatic lesions and is activated by tazarotene in skin rafts and in epidermis of psoriatic lesions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Targeting copper death genotyping associated gene RARRES2 suppresses glioblastoma progression and macrophages infiltration.

Cancer cell international

Yan T,Yang H,Meng Y,Li H,Jiang Q,Liu J,Xu C,Xue Y,Xu J,Song Y,Chu X,Wang L,Chen X,Che F

Mon May 29 00:00:00 UTC 2023

Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression.

Frontiers in pharmacology

Yu M,Yang Y,Zhao H,Li M,Chen J,Wang B,Xiao T,Huang C,Zhao H,Zhou W,Zhang JV

Thu Dec 22 00:00:00 UTC 2022

Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression.

Frontiers in pharmacology

Yu M,Yang Y,Zhao H,Li M,Chen J,Wang B,Xiao T,Huang C,Zhao H,Zhou W,Zhang JV

Thu Dec 22 00:00:00 UTC 2022

Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression.

Frontiers in pharmacology

Yu M,Yang Y,Zhao H,Li M,Chen J,Wang B,Xiao T,Huang C,Zhao H,Zhou W,Zhang JV

Thu Dec 22 00:00:00 UTC 2022

Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression.

Frontiers in pharmacology

Yu M,Yang Y,Zhao H,Li M,Chen J,Wang B,Xiao T,Huang C,Zhao H,Zhou W,Zhang JV

Thu Dec 22 00:00:00 UTC 2022

Neutrophils Promote Tumor Progression in Oral Squamous Cell Carcinoma by Regulating EMT and JAK2/STAT3 Signaling Through Chemerin.

Frontiers in oncology

Hu X,Xiang F,Feng Y,Gao F,Ge S,Wang C,Zhang X,Wang N

Wed Feb 16 00:00:00 UTC 2022

Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model.

Journal of Zhejiang University. Science. B

Zhou X,Li JQ,Wei LJ,He MZ,Jia J,Zhang JY,Wang SS,Feng L

Fri Nov 19 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: Chemerin; RAR-responsive protein TIG2; retinoic acid receptor responder (tazarotene induced) 2; Retinoic acid receptor responder protein 2; Tazarotene-induced gene 2 protein; TIG-2; TIG2HP10433

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Gene Aliases: 0610007L05Rik; AI303516; HP10433; RARRES2; TIG2

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UniProt ID: (Human) Q99969, (Mouse) Q9DD06

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Entrez Gene ID: (Human) 5919, (Mouse) 71660

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Function(s)

receptor binding protein binding

Process(es)

retinoid metabolic process positive regulation of protein phosphorylation chemotaxis defense response inflammatory response positive regulation of macrophage chemotaxis cell differentiation positive regulation of fat cell differentiation embryonic digestive tract development brown fat cell differentiation positive regulation of chemotaxis regulation of lipid catabolic process positive regulation of glucose import in response to insulin stimulus in utero embryonic development platelet degranulation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Chemerin Polyclonal Antibody

Chemerin Antibody (10216-1-AP) in IHC (P)

Product Details

10216-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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