Invitrogen

Chromogranin A Monoclonal Antibody (SP12)

2 Published Figures

11 References

View all (115) Chromogranin A antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (4)
Published Figures (2)

Chromogranin A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

Chromogranin A Antibody (MA5-14536) in IHC (P)

Formalin-fixed, paraffin-embedded human pancreas stained with Chromogranin A using peroxidase-conjugate and AEC. Note cytoplasmic staining of islet cells

Chromogranin A Antibody in Western Blot (WB)

Chromogranin A Antibody in Immunocytochemistry (ICC/IF)

Product Image Gallery

Product Details

MA5-14536

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:5,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

SP12

Immunogen

Recombinant protein encoding human chromogranin A

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant/TBS, pH 7.5, with 1% BSA

Contains

0.1% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_10978165

Product Specific Information

MA5-14536 targets Chromogranin A in WB, and IHC (P) applications and shows reactivity with Human and Rat samples. This antibody does not cross-react with mouse tissues in IHC applications.

The MA5-14536 immunogen is recombinant protein encoding human chromogranin A.

Target Information

Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.

Nature communications

Santos MCFD,Anderson CP,Neschen S,Zumbrennen-Bullough KB,Romney SJ,Kahle-Stephan M,Rathkolb B,Gailus-Durner V,Fuchs H,Wolf E,Rozman J,de Angelis MH,Cai WM,Rajan M,Hu J,Dedon PC,Leibold EA

Published figure using Chromogranin A monoclonal antibody (Product # MA5-14536) in Western Blot

Wed Jan 15 00:00:00 UTC 2020

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors.

Stem cell research & therapy

Aigha II,Memon B,Elsayed AK,Abdelalim EM

Published figure using Chromogranin A monoclonal antibody (Product # MA5-14536) in Immunofluorescence

Tue Apr 03 00:00:00 UTC 2018

The Ewing's Sarcoma Family of Tumors of Urinary Bladder: A Case Report and Review of the Literature.

Balkan medical journal

Tonyalı Ş,Yazıcı S,Yeşilırmak A,Ergen A

MA514536 was used in immunohistochemistry to discuss the characteristics of Ewing's Sarcoma family of tumors of urinary bladder

Fri Jul 01 00:00:00 UTC 2016

Histological characterisation and prognostic evaluation of 62 gastric neuroendocrine carcinomas.

Contemporary oncology (Poznan, Poland)

Deng Y,Chen X,Ye Y,Shi X,Zhu K,Huang L,Zhang S,Ying M,Lin X

MA514536 was used in immunohistochemistry - paraffin section to find prognostic factors for gastric neuroendocrine carcinoma

Fri Sep 30 00:00:00 UTC 2016

Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors.

Endoscopy

Hasegawa T,Yamao K,Hijioka S,Bhatia V,Mizuno N,Hara K,Imaoka H,Niwa Y,Tajika M,Kondo S,Tanaka T,Shimizu Y,Kinoshita T,Kohsaki T,Nishimori I,Iwasaki S,Saibara T,Hosoda W,Yatabe Y

MA5-14536 was used in immunohistochemistry to study the malignancy risk of pancreatic neuroendocrine tumors based on the Ki67 index of endoscopic ultrasound-guided fine-needle aspiration samples

Wed Jan 01 00:00:00 UTC 2014

Insulinoma diagnosed as drug-refractory epilepsy in an adolescent boy: a case report.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

Horváth E,Gozar H,Chira L,Dunca I,Kiss E,Pávai Z

MA5-14536 was used in immunohistochemistry to report on a case of pediatric insulinoma

Wed Jul 02 00:00:00 UTC 2014

Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review.

Sao Paulo medical journal = Revista paulista de medicina

Alvarenga CA,Lopes JM,Vinagre J,Paravidino PI,Alvarenga M,Prando A,Castilho LN,Soares P,Billis A

MA5-14536 was used in immunohistochemistry to report on a case of paraganglioma of seminal vesicle and chromophobe renal cell carcinoma

Thu Oct 04 00:00:00 UTC 2012

Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review.

Diagnostic pathology

Yin WH,Li J,Chan JK

MA5-14536 was used in immunohistochemistry to report on a case of sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression

Thu Apr 12 00:00:00 UTC 2012

Pigmented paraganglioma of the kidney: a case report.

Diagnostic pathology

Zhao L,Luo J,Zhang H,Da J

MA5-14536 was used in immunohistochemistry to report on a case of pigmented paraganglioma of the kidney

Thu Jun 28 00:00:00 UTC 2012

Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Terris B,Genevay M,Rouquette A,Audebourg A,Mentha G,Dousset B,Rubbia-Brandt L

MA5-14536 was used in immunohistochemistry to report three clinical cases of acinar cell carcinoma without intrapancreatic tumour

Thu Dec 01 00:00:00 UTC 2011

Skip metastase on the left neck lymph nodes of the prostatic adenocarcinoma with neuroendocrine differentiation and accompanying thyroid micropapillary carcinoma.

Pathology oncology research : POR

Sagnak L,Topaloglu H,Gucuk O,Han U,Ersoy H

MA5-14536 was used in immunohistochemistry to report a clinical case of thyroid micropapillary carcinoma with unique features

Mon Dec 01 00:00:00 UTC 2008

Bioinformatics

Protein Aliases: betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; chromofungin; Chromogranin-A; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I

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Gene Aliases: CGA; CHGA

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UniProt ID: (Human) P10645

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Entrez Gene ID: (Human) 1113, (Rat) 24258

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Function(s)

protein binding

Process(es)

regulation of the force of heart contraction organelle organization positive regulation of cAMP metabolic process ovulation cycle negative regulation of vasodilation positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway negative regulation of neuron death mast cell chemotaxis regulation of blood pressure killing of cells of other organism mast cell cytokine production negative regulation of catecholamine secretion mast cell degranulation innate immune response mast cell activation defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to fungus positive regulation of cardiac muscle contraction adrenergic receptor signaling pathway involved in cardiac muscle relaxation positive regulation of relaxation of cardiac muscle positive regulation of dense core granule biogenesis

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Chromogranin A Monoclonal Antibody (SP12)

Chromogranin A Antibody (MA5-14536) in IHC (P)

Product Details

MA5-14536

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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