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Product Details
651122
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
139.3.4
Immunogen
Synthetic Peptide (Aa. 4-24)
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Specificity: cingulin (a 150 kD polypeptide) present in tight junctions (zonula occludens) of polar epithelia (e.g. colon, duodenum, kidney, liver, pancreas), of transitional epithelia (e.g. bladder epithelium), and of stratified epithelia (e.g. skin, foot sole, tongue, oesophagus, vagina).Negative with endothelia of vessels and capillaries (e.g. in heart and brain). Polypeptide reacting: Cingulin, 126.5 kD polypeptide (calculated from aa sequence data); apparent MW 150 kD (after SDS-PAGE); pI 6.5 (very similar to symplekin, another junctional protein).Reactivity on cultured cell lines: Carcinoma cell lines (e.g. MCF-7, Caco-2, PLC, A-431), SV80 (fibroblasts), Glioma; MDBK, MDCK, BMGE.
Target Information
Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cingulin
Gene Aliases: 6330408J11Rik; BOS_2977; CGN; KIAA1319
UniProt ID: (Human) Q9P2M7
Entrez Gene ID: (Human) 57530, (Bovine) 533725, (Mouse) 70737
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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