Proteintech

Claspin Polyclonal Antibody

Claspin Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

Claspin Antibody (23206-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 23206-1-AP (Claspin antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Claspin Antibody in Immunoprecipitation (IP)

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Product Details

23206-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Claspin Fusion Protein Ag19637 (1-354 aa encoded by BC137279)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MTGEVGSEV HLEINDPNVI SQEEADSPSD SGQGSYETIG PLSEGDSDEE IFVSKKLKNR KVLQDSDSET EDTNASPEKT TYDSAEEENK ENLYAGKNTK IKRIYKTVAD SDESYMEKSL YQENLEAQVK PCLELSLQSG NSTDFTTDRK SSKKHIHDKE GTAGKAKVKS KRRLEKEERK MEKIRQLKKK ETKNQEDDVE QPFNDSGCLL VDKDLFETGL EDENNSPLED EESLESIRAA VKNKVKKHKK KEPSLESGVH SFEEGSELSK GTTRKERKAA RLSKEALKQL HSETQRLIRE SALNLPYHMP ENKTIHDFFK RKPRPTCHGN AMALLKSSKY QSSHHKEIID TANTT (1-354 aa encoded by BC137279)

Target Information

Xenopus claspin is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in the presence of DNA templates in Xenopus egg extracts. The human gene appears to be the homolog Xenopus claspin and its function has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.

Cellular and molecular life sciences : CMLS

Arasu UT,Deen AJ,Pasonen-Seppänen S,Heikkinen S,Lalowski M,Kärnä R,Härkönen K,Mäkinen P,Lázaro-Ibáñez E,Siljander PR,Oikari S,Levonen AL,Rilla K

Thu Oct 01 00:00:00 UTC 2020

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.

Cellular and molecular life sciences : CMLS

Arasu UT,Deen AJ,Pasonen-Seppänen S,Heikkinen S,Lalowski M,Kärnä R,Härkönen K,Mäkinen P,Lázaro-Ibáñez E,Siljander PR,Oikari S,Levonen AL,Rilla K

Thu Oct 01 00:00:00 UTC 2020

Deubiquitinating enzyme USP20 is a positive regulator of Claspin and suppresses the malignant characteristics of gastric cancer cells.

International journal of oncology

Wang C,Yang C,Ji J,Jiang J,Shi M,Cai Q,Yu Y,Zhu Z,Zhang J

Sat Apr 01 00:00:00 UTC 2017

Deubiquitinating enzyme USP20 is a positive regulator of Claspin and suppresses the malignant characteristics of gastric cancer cells.

International journal of oncology

Wang C,Yang C,Ji J,Jiang J,Shi M,Cai Q,Yu Y,Zhu Z,Zhang J

Sat Apr 01 00:00:00 UTC 2017

Deubiquitinating enzyme USP20 is a positive regulator of Claspin and suppresses the malignant characteristics of gastric cancer cells.

International journal of oncology

Wang C,Yang C,Ji J,Jiang J,Shi M,Cai Q,Yu Y,Zhu Z,Zhang J

Sat Apr 01 00:00:00 UTC 2017

Deubiquitinating enzyme USP20 is a positive regulator of Claspin and suppresses the malignant characteristics of gastric cancer cells.

International journal of oncology

Wang C,Yang C,Ji J,Jiang J,Shi M,Cai Q,Yu Y,Zhu Z,Zhang J

Sat Apr 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Claspin; claspin homolog; hClaspin; MGC131612; MGC131613; MGC131615

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Gene Aliases: CLSPN

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UniProt ID: (Human) Q9HAW4

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Entrez Gene ID: (Human) 63967

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Function(s)

DNA binding protein binding anaphase-promoting complex binding

Process(es)

DNA damage checkpoint DNA replication DNA repair cellular component disassembly involved in execution phase of apoptosis peptidyl-serine phosphorylation G2 DNA damage checkpoint activation of protein kinase activity mitotic DNA replication checkpoint

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Claspin Polyclonal Antibody

Claspin Antibody (23206-1-AP) in ICC/IF

Product Details

23206-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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