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CHC5.9 represents an excellent marker for detection of receptor mediated endocytosis.Reactive polypeptide: MW 180 000 polypeptide (clathrin heavy chain) from coated vesicles of various tissues.Structures and tissues specifically detected: Coated vesicles of different organs and tissues (eg brain, mammary gland, ovaries).Reactivity on cultured cell lines: HeLa, SV-40, RVF-SMC.
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: clathrin heavy chain; Clathrin heavy chain 1; Clathrin heavy chain 2; Clathrin heavy chain on chromosome 17; Clathrin heavy chain on chromosome 22; clathrin, heavy chain (Hc); clathrin, heavy chain-like 1; clathrin, heavy polypeptide (Hc); Clathrin, heavy polypeptide D; clathrin, heavy polypeptide-like 1; clathrin, heavy polypeptide-like 2; CLH-17; CLH-22
Gene Aliases: BOS_18343; CHC; CHC17; CHC22; CLH-17; CLH17; CLH22; CLTC; CLTCL; CLTCL1; CLTCL2; CLTD; Hc; KIAA0034
UniProt ID: (Human) Q00610, (Bovine) P49951, (Human) P53675, (Rat) P11442
Entrez Gene ID: (Human) 1213, (Pig) 100271929, (Bovine) 281080, (Human) 8218, (Rat) 54241
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