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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Claudin 1 Antibodies

          Invitrogen

          Claudin 1 Monoclonal Antibody (2H10D10)

          Advanced Verification
          62 Published Figures
          116 References
          View all (22) Claudin 1 antibodies

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          Datasheet
          Protocols
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          Datasheet
          Protocols
          Questions & Answers

          Cite Claudin 1 Monoclonal Antibody (2H10D10)

          • Antibody Testing Data (6)
          • Published Figures (62)
          • Advanced Verification (2)
          Claudin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Claudin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 70

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          Claudin 1 Antibody (37-4900) in IHC (P)

          Immunohistochemistry analysis of Claudin 1 showing staining in the Membrane and Cytoplasm of paraffin-embedded human kidney tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at roo... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Claudin 1 Antibody in Immunohistochemistry (Frozen) (IHC (F))
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Claudin 1 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunocytochemistry (ICC/IF)
          Claudin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Claudin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Claudin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Claudin 1 Antibody in Immunohistochemistry (IHC)
          Claudin 1 Antibody in Immunohistochemistry (IHC)
          Claudin 1 Antibody in Immunohistochemistry (IHC)
          Claudin 1 Antibody in Immunohistochemistry (IHC)
          Claudin 1 Antibody in Western Blot, Immunohistochemistry (WB, IHC)
          Claudin 1 Antibody in Immunohistochemistry (IHC)
          Claudin 1 Antibody in Immunohistochemistry (IHC)
          Claudin 1 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody in Western Blot (WB)
          Claudin 1 Antibody
          Claudin 1 Antibody

          Product Details

          37-4900

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1-3 µg/mL
          View 52 publications 52 publications

          Immunohistochemistry (IHC)

          -
          View 14 publications 14 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          Assay-dependent
          View 7 publications 7 publications

          Immunohistochemistry (PFA fixed) (IHC (PFA))

          -
          View 1 publication 1 publication

          Immunohistochemistry (Frozen) (IHC (F))

          5-10 µg/mL
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          1-5 µg/mL
          View 24 publications 24 publications

          Flow Cytometry (Flow)

          -
          View 1 publication 1 publication

          ELISA (ELISA)

          0.1-1.0 µg/mL
          -

          Immunoprecipitation (IP)

          10 µg/test
          -

          Miscellaneous PubMed (MISC)

          -
          View 16 publications 16 publications
          Product Specifications

          Species Reactivity

          Dog, Human, Mouse, Rat

          Published species

          Chicken, Dog, Human, Mouse, Pig, Rabbit, Rat, Rhesus monkey

          Host/Isotype

          Mouse / IgG1

          Class

          Monoclonal

          Type

          Antibody

          Clone

          2H10D10

          Immunogen

          Synthetic peptide derived from the C-terminal region of the human and mouse claudin-1 proteins
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated
          • Alexa Fluor 488 
          • Request custom conjugation

          Form

          Liquid

          Concentration

          0.5 mg/mL

          Purification

          Protein A

          Storage buffer

          PBS, pH 7.4

          Contains

          0.1% sodium azide

          Storage conditions

          Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2533323

          Product Specific Information

          Reactivity has been confirmed with human Caco-2 and canine MDCK cell lysates, mouse kidney and intestinal lysates, frozen mouse intestine (jejunum) tissue, and rat kidney homogenates.

          This antibody is specific for the C-terminal region of the claudin-1 protein. On western blots, it identifies the target band at ~22 kDa.

          Target Information

          Claudin-1 is a member of the transmembrane protein family claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian tube, liver, pancreas, prostate, and skin.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Claudin-1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1

          View more View less

          Gene Aliases: AI596271; CLD1; CLDN1; ILVASC; SEMP1; UNQ481/PRO944

          View more View less

          UniProt ID: (Human) O95832, (Rat) P56745, (Mouse) O88551

          View more View less

          Entrez Gene ID: (Dog) 608207, (Human) 9076, (Rat) 65129, (Mouse) 12737

          View more View less

          Function(s)
          virus receptor activity structural molecule activity protein binding identical protein binding
          Process(es)
          calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell-cell junction organization establishment of skin barrier viral entry into host cell protein homooligomerization protein heterooligomerization bicellular tight junction assembly
          It has to be done as per old AB suggested Products section.
          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
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          We're here to help

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