Product References
The Local Activation of Toll-like Receptor 7 (TLR7) Modulates Colonic Epithelial Barrier Function in Rats.
International journal of molecular sciences
Estévez J,Martínez V
32-5600 was used in Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to show that TLR7 stimulation leads to the modulation of the colonic EBF, having beneficial or detrimental effects depending upon the state of the epithelium.
Mon Jan 09 00:00:00 UTC 2023
Dose- and Segment-Dependent Disturbance of Rat Gut by Ionizing Radiation: Impact of Tight Junction Proteins.
International journal of molecular sciences
Livanova AA,Fedorova AA,Zavirsky AV,Krivoi II,Markov AG
32-5600 was used in Western Blot to demonstrate the dose- and segment-specificity of tight junction (TJ) alteration in ionizing radiation (IR)-induced gastrointestinal injury in rats.
Mon Jan 16 00:00:00 UTC 2023
Disruption to tRNA Modification by Queuine Contributes to Inflammatory Bowel Disease.
Cellular and molecular gastroenterology and hepatology
Zhang J,Zhang Y,McGrenaghan CJ,Kelly VP,Xia Y,Sun J
32-5600 was used in Western Blot to explore the Q-tRNA modifications and expression of QTRT1 (queuine tRNA-ribosyltransferase 1) in patients with IBD by investigating human biopsies and reanalyzing datasets.
Mon May 22 00:00:00 UTC 2023
Maternal Epidermal Growth Factor Promotes Neonatal Claudin-2 Dependent Increases in Small Intestinal Calcium Permeability.
Function (Oxford, England)
Beggs MR,Young K,Plain A,O'Neill DD,Raza A,Flockerzi V,Dimke H,Alexander RT
32-5600 was used in Western Blot to support intestinal permeability to calcium, conferred by claudin-2, being greater in suckling mice and being driven by EGF in breast milk.
Wed Aug 16 00:00:00 UTC 2023
Characterization of the pattern of expression of Gas1 in the kidney during postnatal development in the rat.
PloS one
Cetina-Palma A,Namorado-Tónix C,Rodríguez-Muñoz R,Vergara P,Reyes-Sánchez JL,Segovia J
32-5600 was used in Immunohistochemistry to characterize the expression pattern of Gas1 in the different regions of the kidney during the postnatal development of the rat.
Wed Apr 26 00:00:00 UTC 2023
Characterization of the pattern of expression of Gas1 in the kidney during postnatal development in the rat.
PloS one
Cetina-Palma A,Namorado-Tónix C,Rodríguez-Muñoz R,Vergara P,Reyes-Sánchez JL,Segovia J
32-5600 was used in Immunohistochemistry to characterize the expression pattern of Gas1 in the different regions of the kidney during the postnatal development of the rat.
Wed Apr 26 00:00:00 UTC 2023
The effect of occlusal disharmony on a chronic stress-induced animal model of gut microbiota dysbiosis.
Journal of oral rehabilitation
Wu L,Zhang S,Zhang M,Wang X,Li S,Rausch-Fan X,Chen J
32-5600 was used in Immunohistochemistry and Western blotting to conclude that the significant changes in performance on behavioural tests, serum corticosterone concentrations and microbiota dysbiosis and tight junction protein levels induced by OD with CS may indicate that OD is a potential factor promoting gut microbiota dysbiosis.
Wed Mar 01 00:00:00 UTC 2023
The effect of occlusal disharmony on a chronic stress-induced animal model of gut microbiota dysbiosis.
Journal of oral rehabilitation
Wu L,Zhang S,Zhang M,Wang X,Li S,Rausch-Fan X,Chen J
32-5600 was used in Immunohistochemistry and Western blotting to conclude that the significant changes in performance on behavioural tests, serum corticosterone concentrations and microbiota dysbiosis and tight junction protein levels induced by OD with CS may indicate that OD is a potential factor promoting gut microbiota dysbiosis.
Wed Mar 01 00:00:00 UTC 2023
Human Colonoid-Myofibroblast Coculture for Study of Apical Na+/H+ Exchangers of the Lower Cryptal Neck Region.
International journal of molecular sciences
Salari A,Zhou K,Nikolovska K,Seidler U,Amiri M
32-5600 was used in Immunohistochemistry to establish an in vitro model of the colonic lower crypt compartment, which expresses the transit amplifying/progenitor (TA/PE) cells, with accessibility of the apical membrane for functional study of lower crypt-expressed Na+/H+ exchangers (NHEs).
Tue Feb 21 00:00:00 UTC 2023
Selective Role of TNFα and IL10 in Regulation of Barrier Properties of the Colon in DMH-Induced Tumor and Healthy Rats.
International journal of molecular sciences
Bekusova V,Zudova T,Fatyykhov I,Fedorova A,Amasheh S,Markov AG
32-5600 was used in Western Blotting to indicate a selective role of the cytokines in regulation of the barrier properties of the colon and a prominent role of IL10 in carcinogenesis in its proximal part.
Fri Dec 09 00:00:00 UTC 2022
Transcriptomic Analysis of Testicular Gene Expression in a Dog Model of Experimentally Induced Cryptorchidism.
Cells
Jhun H,Lee WY,Park JK,Hwang SG,Park HJ
32-5600 was used in Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry to indicate that testicular hyperthermia caused by cryptorchidism affects claudin expression, regulated germ cell death, and the proliferation of Sertoli cells.
Wed Aug 10 00:00:00 UTC 2022
MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier.
Cells
Weiß F,Czichos C,Knobe L,Voges L,Bojarski C,Michel G,Fromm M,Krug SM
32-5600 was used in Western Blotting to conclude that the protective effects are hardly targeting the intestinal barrier directly but are based on regulatory processes supporting stabilization of the intestinal barrier.
Wed May 04 00:00:00 UTC 2022
Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.
Nature communications
Gonschior H,Schmied C,Van der Veen RE,Eichhorst J,Himmerkus N,Piontek J,Günzel D,Bleich M,Furuse M,Haucke V,Lehmann M
32-5600 was used in Immunocytochemistry to suggest that nanoscale segregation of distinct channel-forming claudins enables barrier function combined with specific paracellular ion flux across tight junctions.
Thu Aug 25 00:00:00 UTC 2022
Loss of Ecrg4 improves calcium oxalate nephropathy.
PloS one
Cabuzu D,Ramakrishnan SK,Moor MB,Harmacek D,Auberson M,Durussel F,Bonny O
32-5600 was used in Western Blotting to study the function of esophageal cancer-related gene 4 (Ecrg4) in renal tissue and its relationship with calciuria.
Mon Oct 17 00:00:00 UTC 2022
ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions.
Cells
Haas AJ,Zihni C,Krug SM,Maraspini R,Otani T,Furuse M,Honigmann A,Balda MS,Matter K
32-5600 was used in Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to reveal that reciprocal regulation between ZO-1 and cell mechanics controls tight junction assembly and epithelial morphogenesis, and that, in a second, tension-independent step, ZO-1 is required to assemble morphologically and structurally fully assembled and functionally normal tight junctions.
Fri Nov 25 00:00:00 UTC 2022
Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration Across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis.
Journal of Crohn's & colitis
Nighot M,Ganapathy AS,Saha K,Suchanec E,Castillo EF,Gregory A,Shapiro S,Ma T,Nighot P
32-5600 was used in Western Blotting to demonstrate that MMP-12 mediated degradation of basement membrane laminin, macrophage transmigration, and associated loss of intestinal TJ barrier are key pathogenic factors for intestinal inflammation.
Thu Oct 07 00:00:00 UTC 2021
Angulin-1 seals tricellular contacts independently of tricellulin and claudins.
The Journal of cell biology
Sugawara T,Furuse K,Otani T,Wakayama T,Furuse M
32-5600 was used in Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry to investigate the roles of angulin-1 and tricellulin in tTJ formation in MDCK II cells by genome editing. Angulin-1-deficient cells lost the plasma membrane contact at TCs with impaired epithelial barrier function.
Mon Sep 06 00:00:00 UTC 2021
Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome.
Journal of gastroenterology and hepatology
Miura K,Oshima T,Ito C,Horikawa T,Yamada M,Tomita T,Fukui H,Miwa H
32-5600 was used in Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to demonstrate that protein expression level of VDR an number of mast cells are elevated in the duodenal epithelial crypt in patients with IBS.
Thu Apr 01 00:00:00 UTC 2021
Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron.
American journal of physiology. Renal physiology
Nelson JW,McDonough AA,Xiang Z,Ralph DL,Robertson JA,Giani JF,Bernstein KE,Gurley SB
32-5600 was used in Western Blotting to determine how loss of angiotensin II signaling in the proximal tubule (PT), which reabsorbs the bulk of filtered Na+ and volume, impacts solute transport throughout the nephron.
Thu Jul 01 00:00:00 UTC 2021
Protective Functions of ZO-2/Tjp2 Expressed in Hepatocytes and Cholangiocytes Against Liver Injury and Cholestasis.
Gastroenterology
Xu J,Kausalya PJ,Van Hul N,Caldez MJ,Xu S,Ong AGM,Woo WL,Mohamed Ali S,Kaldis P,Hunziker W
32-5600 was used in Western Blotting to characterize mice with liver-specific inactivation of Tjp2.
Sat May 01 00:00:00 UTC 2021
Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles.
American journal of physiology. Cell physiology
Torres-Pinzon DL,Ralph DL,Veiras LC,McDonough AA
32-5600 was used in Western Blot to test the hypothesis that adaptations to HS diet along the nephron will exhibit sexual dimorphisms.
Mon Nov 01 00:00:00 UTC 2021
Effects of 1,2-Dimethylhydrazine on Barrier Properties of Rat Large Intestine and IPEC-J2 Cells.
International journal of molecular sciences
Bekusova V,Droessler L,Amasheh S,Markov AG
32-5600 was used in Western Blotting to show that the increase of claudin-4 in rat colon after chronic DMH exposure was consistent with the acute effect of DMH on IPEC-J2 cells, which may indicate an essential role of this protein in colorectal cancer development.
Fri Sep 24 00:00:00 UTC 2021
T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.
The Journal of clinical investigation
Marchelletta RR,Krishnan M,Spalinger MR,Placone TW,Alvarez R,Sayoc-Becerra A,Canale V,Shawki A,Park YS,Bernts LH,Myers S,Tremblay ML,Barrett KE,Krystofiak E,Kachar B,McGovern DP,Weber CR,Hanson EM,Eckmann L,McCole DF
32-5600 was used in Immunohistochemistry to demonstrate that TCPTP protected against intestinal barrier dysfunction induced by the inflammatory cytokine IFN-γ by 2 mechanisms: it maintained localization of zonula occludens 1 and occludin at apical tight junctions and restricted both expression and insertion of the cation pore-forming transmembrane protein, claudin-2, at tight junctions through upregulation of the inhibitory cysteine protease, matriptase.
Wed Sep 01 00:00:00 UTC 2021
T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.
The Journal of clinical investigation
Marchelletta RR,Krishnan M,Spalinger MR,Placone TW,Alvarez R,Sayoc-Becerra A,Canale V,Shawki A,Park YS,Bernts LH,Myers S,Tremblay ML,Barrett KE,Krystofiak E,Kachar B,McGovern DP,Weber CR,Hanson EM,Eckmann L,McCole DF
32-5600 was used in Immunohistochemistry to demonstrate that TCPTP protected against intestinal barrier dysfunction induced by the inflammatory cytokine IFN-γ by 2 mechanisms: it maintained localization of zonula occludens 1 and occludin at apical tight junctions and restricted both expression and insertion of the cation pore-forming transmembrane protein, claudin-2, at tight junctions through upregulation of the inhibitory cysteine protease, matriptase.
Wed Sep 01 00:00:00 UTC 2021
Disruption of the pro-inflammatory, anti-inflammatory cytokines and tight junction proteins expression, associated with changes of the composition of the gut microbiota in patients with irritable bowel syndrome.
PloS one
Ivashkin V,Poluektov Y,Kogan E,Shifrin O,Sheptulin A,Kovaleva A,Kurbatova A,Krasnov G,Poluektova E
32-5600 was used in Immunohistochemistry to assess the changes of gut microbiome composition, tight junction proteins, and cytokines expression of intestinal mucosa from the duodenum to the distal part of the colon in irritable bowel syndrome patients and healthy volunteers.
Tue Nov 16 00:00:00 UTC 2021
Standardization of esophageal adenocarcinoma in vitro model and its applicability for model drug testing.
Scientific reports
Tratnjek L,Sibinovska N,Kralj S,Makovec D,Kristan K,Kreft ME
32-5600 was used in Immunocytochemistry-immunoflourescence to characterize FLO-1 cell line under different culturing conditions with the aim of (1) examining the effect of serum-free growth medium and air-liquid interface (A-L) culturing, which better reflect physiological conditions in vivo and (2) investigating the differentiation potential of FLO-1 cells to mimic the properties of the in vivo esophageal epithelium.
Tue Mar 23 00:00:00 UTC 2021
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels.
Biology
Huang X,Oshima T,Tomita T,Fukui H,Miwa H
32-5600 was used in Western Blot to suggest that butyrate is the main component of SCFAs to alleviate barrier dysfunction and that claudin-2 is the major target of this SCFA.
Tue Mar 09 00:00:00 UTC 2021
Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern.
Communications biology
Tabariès S,Annis MG,Lazaris A,Petrillo SK,Huxham J,Abdellatif A,Palmieri V,Chabot J,Johnson RM,Van Laere S,Verhoef C,Hachem Y,Yumeen S,Meti N,Omeroglu A,Altinel G,Gao ZH,Yu ASL,Grünhagen DJ,Vermeulen P,Metrakos P,Siegel PM
32-5600 was used in Western Blot to provide evidence that Claudin-2 status in patient-derived extracellular vesicles may serve as a relevant prognostic biomarker to predict whether colorectal cancer patients have developed replacement type liver metastases.
Wed Jun 02 00:00:00 UTC 2021
Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells.
Cellular and molecular gastroenterology and hepatology
Caron TJ,Scott KE,Sinha N,Muthupalani S,Baqai M,Ang LH,Li Y,Turner JR,Fox JG,Hagen SJ
32-5600 was used in Immunohistochemistry (Paraffin) to suggest that Cldn18-KO has no effect on tight junction permeability in the stomach from adult mice but rather affects anion permeability.
Mon Dec 20 00:00:00 UTC 2021
Regulation of Intestinal Epithelial Barrier and Immune Function by Activated T Cells.
Cellular and molecular gastroenterology and hepatology
Le N,Mazahery C,Nguyen K,Levine AD
32-5600 was used in Immunocytochemistry to conclude that bidirectional communication between T cells and epithelium mediates a biphasic response in barrier integrity that is facilitated by the balance between structural proteins partitioning in the mobile lateral phase vs the tight junction complex and cell morphology.
Mon Dec 20 00:00:00 UTC 2021
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Cancer cell
Marjanovic ND,Hofree M,Chan JE,Canner D,Wu K,Trakala M,Hartmann GG,Smith OC,Kim JY,Evans KV,Hudson A,Ashenberg O,Porter CBM,Bejnood A,Subramanian A,Pitter K,Yan Y,Delorey T,Phillips DR,Shah N,Chaudhary O,Tsankov A,Hollmann T,Rekhtman N,Massion PP,Poirier JT,Mazutis L,Li R,Lee JH,Amon A,Rudin CM,Jacks T,Regev A,Tammela T
32-5600 was used in Immunohistochemistry to profile cellular transcriptomes of lung tumours at different stages.
Mon Aug 10 00:00:00 UTC 2020
Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease.
The Journal of clinical investigation
Curry JN,Saurette M,Askari M,Pei L,Filla MB,Beggs MR,Rowe PS,Fields T,Sommer AJ,Tanikawa C,Kamatani Y,Evan AP,Totonchi M,Alexander RT,Matsuda K,Yu AS
32-5600 was used in Western Blotting to show that claudin-2 is a key regulator of calcium excretion and a potential target for therapies to prevent kidney stones.
Wed Apr 01 00:00:00 UTC 2020
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice.
The Journal of clinical investigation
Raju P,Shashikanth N,Tsai PY,Pongkorpsakol P,Chanez-Paredes S,Steinhagen PR,Kuo WT,Singh G,Tsukita S,Turner JR
32-5600 was used in an ELISA assay to define the impact of claudin-2 channels on disease using mice models.
Thu Oct 01 00:00:00 UTC 2020
The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction.
Inflammatory bowel diseases
Sayoc-Becerra A,Krishnan M,Fan S,Jimenez J,Hernandez R,Gibson K,Preciado R,Butt G,McCole DF
32-5600 was used in Western Blotting to determine if JAK inhibition by tofacitinib can rescue cytokine-induced barrier dysfunction in intestinal epithelial cells (IECs).
Tue Feb 11 00:00:00 UTC 2020
Intestinal vitamin D receptor signaling ameliorates dextran sulfate sodium-induced colitis by suppressing necroptosis of intestinal epithelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shi Y,Cui X,Sun Y,Zhao Q,Liu T
32-5600 was used in Western Blotting to offer some theoretical basis for a novel treatment of IBD in clinical practice.
Thu Oct 01 00:00:00 UTC 2020
Combinatorial expression of claudins in the proximal renal tubule and its functional consequences.
American journal of physiology. Renal physiology
Curry JN,Tokuda S,McAnulty P,Yu ASL
32-5600 was used in Immunohistochemistry to determine the expression pattern of the major PT claudins. We found that claudin-2 and claudin-10 are coexpressed throughout the PT, whereas claudin-3 is coexpressed with claudin-2 predominantly in the proximal straight tubule.
Fri May 01 00:00:00 UTC 2020
Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate In Vitro Transport in Primary Renal Tubule Cells.
Tissue engineering. Part A
Love H,Evans R,Humes HD,Roy S,Zent R,Harris R,Wilson M,Fissell WH
32-5600 was used in Immunocytochemistry-immunoflourescence to show that addition of metformin increased transport, in the context of a transient effect on 5' AMP-activated kinase phosphorylation.
Thu Oct 01 00:00:00 UTC 2020
Enteropathogenic Escherichia coli Infection Induces Diarrhea, Intestinal Damage, Metabolic Alterations, and Increased Intestinal Permeability in a Murine Model.
Frontiers in cellular and infection microbiology
Ledwaba SE,Costa DVS,Bolick DT,Giallourou N,Medeiros PHQS,Swann JR,Traore AN,Potgieter N,Nataro JP,Guerrant RL
32-5600 was used in Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to develop a murine infection model treated with antibiotics to mimic clinical outcomes seen in children with EPEC infection.
Thu Jun 17 00:00:00 UTC 2021
Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis.
Cell death & disease
Shi Y,Liu Z,Cui X,Zhao Q,Liu T
32-5600 was used in Western Blotting to identify that intestinal vitamin D receptor knockout protected against oxazolone-induced colitis in mice by blocking Th2 cell response and reducing the function of intestinal invariant natural killer T cells.
Mon Jun 15 00:00:00 UTC 2020
Altered Structural Expression and Enzymatic Activity Parameters in Quiescent Ulcerative Colitis: Are These Potential Normalization Criteria?
International journal of molecular sciences
Kjærgaard S,Damm MMB,Chang J,Riis LB,Rasmussen HB,Hytting-Andreasen R,Krug SM,Schulzke JD,Bindslev N,Hansen MB
32-5600 was used in Immunohistochemistry to study mucosal healing on a molecular and functional level in quiescent ulcerative colitis (UC).
Tue Mar 10 00:00:00 UTC 2020
Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels.
International journal of molecular sciences
Markov AG,Fedorova AA,Kravtsova VV,Bikmurzina AE,Okorokova LS,Matchkov VV,Cornelius V,Amasheh S,Krivoi II
32-5600 was used in Western Blotting to confirm that circulating ouabain can functionally and tissue-specifically affect barrier properties of epithelial and endothelial tissues via Na,K-ATPase-mediated modulation of claudins expression.
Fri Jul 17 00:00:00 UTC 2020
Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease.
Cell communication and signaling : CCS
Price GW,Chadjichristos CE,Kavvadas P,Tang SCW,Yiu WH,Green CR,Potter JA,Siamantouras E,Squires PE,Hills CE
32-5600 was used in Western Blotting to suggest that Cx43 mediated ATP release represents an initial trigger in early tubular injury via its actions on the adherens and tight junction complex.
Mon May 25 00:00:00 UTC 2020
Claudin-12 Knockout Mice Demonstrate Reduced Proximal Tubule Calcium Permeability.
International journal of molecular sciences
Plain A,Pan W,O'Neill D,Ure M,Beggs MR,Farhan M,Dimke H,Cordat E,Alexander RT
32-5600 was used in Western Blotting to examine claudin-12 renal localization and its contribution to tubular paracellular calcium permeability.
Wed Mar 18 00:00:00 UTC 2020
Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice.
Frontiers in pharmacology
Cai TT,Ye XL,Li RR,Chen H,Wang YY,Yong HJ,Pan ML,Lu W,Tang Y,Miao H,Snijders AM,Mao JH,Liu XY,Lu YB,Ding DF
32-5600 was used in Immunohistochemistry to detemine whether the anti-DN effects of resveratrol are mediated through modulation of the gut microbiota using the genetic db/db mouse model of DN. To demonstrate that resveratrol treatment of db/db mice relieves a series of clinical indicators of DN and they show that resveratrol improves intestinal barrier function and ameliorates intestinal permeability and inflammation.
Tue Oct 06 00:00:00 UTC 2020
Impact of viral disease hypophagia on pig jejunal function and integrity.
PloS one
Helm ET,Curry SM,De Mille CM,Schweer WP,Burrough ER,Gabler NK
32-5600 was used in Immunohistochemistry to determine the impact of Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and feed intake on parameters of jejunal function and integrity in growing pigs.
Fri Apr 10 00:00:00 UTC 2020
Localization of claudin-2 and claudin-3 in eutopic and ectopic endometrium is highly similar.
Archives of gynecology and obstetrics
Hoerscher A,Horné F,Dietze R,Berkes E,Oehmke F,Tinneberg HR,Meinhold-Heerlein I,Konrad L
32-5600 was used in Immunohistochemistry to investigate localization of claudin-2 and claudin-3 in the eutopic and ectopic endometrium.
Wed Apr 01 00:00:00 UTC 2020
In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis.
PloS one
Smith N,Saunders D,Lerner M,Zalles M,Mamedova N,Cheong D,Mohammadi E,Yuan T,Luo Y,Hurst RE,Greenwood-Van Meerveld B,Towner RA
32-5600 was used in Immunohistochemistry, Immunocytochemistry to determine if the URO-MCP-1 mouse model for bladder IC/BPS is associated with in vivo bladder hyper-permeability, as measured by contrast-enhanced MRI (CE-MRI), and assess whether molecular-targeted MRI (mt-MRI) can visualize in vivo claudin-2 expression as a result of bladder hyper-permeability.
Fri Nov 20 00:00:00 UTC 2020
In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis.
PloS one
Smith N,Saunders D,Lerner M,Zalles M,Mamedova N,Cheong D,Mohammadi E,Yuan T,Luo Y,Hurst RE,Greenwood-Van Meerveld B,Towner RA
32-5600 was used in Immunohistochemistry, Immunocytochemistry to determine if the URO-MCP-1 mouse model for bladder IC/BPS is associated with in vivo bladder hyper-permeability, as measured by contrast-enhanced MRI (CE-MRI), and assess whether molecular-targeted MRI (mt-MRI) can visualize in vivo claudin-2 expression as a result of bladder hyper-permeability.
Fri Nov 20 00:00:00 UTC 2020
Afadin cooperates with Claudin-2 to promote breast cancer metastasis.
Genes & development
Tabariès S,McNulty A,Ouellet V,Annis MG,Dessureault M,Vinette M,Hachem Y,Lavoie B,Omeroglu A,Simon HG,Walsh LA,Kimbung S,Hedenfalk I,Siegel PM
32-5600 was used in Western Blotting to study the roles of afadin and claudin-2 in the metastasis of breast cancer.
Fri Feb 01 00:00:00 UTC 2019
Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
The Journal of cell biology
Otani T,Nguyen TP,Tokuda S,Sugihara K,Sugawara T,Furuse K,Miura T,Ebnet K,Furuse M
32-5600 was used in Immunocytochemistry-immunoflourescence to demonstrate that claudins and JAM-A coordinately regulate tight junctions (TJ) formation and epithelial polarity.
Mon Oct 07 00:00:00 UTC 2019
Increased osmolality enhances the tight junction-mediated barrier function in a cultured renal epithelial cell line.
Cell biology international
Canuto LP,Collares-Buzato CB
32-5600 was used in Immunohistochemistry-immunofluorescence to suggest that an increased osmolality induces enhancement of the TJ-mediated barrier of MDCK cells, and that, therefore, the negative effect of high glucose on the epithelial paracellular barrier cannot be attributed to its osmotic actions.
Tue Jan 01 00:00:00 UTC 2019
Toll-like receptor 5-mediated IL-17C expression in intestinal epithelial cells enhances epithelial host defense against F4+ ETEC infection.
Veterinary research
Luo Y,Xu J,Zhang C,Jiang C,Ma Y,He H,Wu Y,Devriendt B,Cox E,Zhang H
32-5600 was used in Western Blotting to study the role of IL-17A during an enterotoxigenic escheria coli infection.
Thu Jun 20 00:00:00 UTC 2019
Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells.
The Journal of biological chemistry
Dan Q,Shi Y,Rabani R,Venugopal S,Xiao J,Anwer S,Ding M,Speight P,Pan W,Alexander RT,Kapus A,Szászi K
32-5600 was used in Western Blot to suggest that the initial CLDN-2 elevation might aid epithelial regeneration, and CLDN-2 loss could contribute to fibrotic reprogramming.
Fri Oct 18 00:00:00 UTC 2019
High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors.
The American journal of pathology
Tawiah A,Moreau F,Kumar M,Tiwari S,Falguera J,Chadee K
32-5600 was used in Western Blot to conclude that high MUC2 output during colitis impairs goblet cell migration and wound healing by reducing production of growth factors critical in wound repair.
Sat Sep 01 00:00:00 UTC 2018
Treatment-related survival associations of claudin-2 expression in fibroblasts of colorectal cancer.
Virchows Archiv : an international journal of pathology
Mezheyeuski A,Strell C,Hrynchyk I,Guren TK,Dragomir A,Doroshenko T,Pashkova O,Gorgun J,Ruksha K,Pfeiffer P,Kure EH,Sorbye H,Edler D,Martling A,Glimelius B,Östman A,Portyanko A
32-5600 was used in Immunocytochemistry-immunoflourescence to investigate expression patterns of claudin-2 in human colorectal cancer samples and analyse its association with clinical characteristics and treatment outcome.
Thu Mar 01 00:00:00 UTC 2018
Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs.
Tissue barriers
Chen H,Lu R,Zhang YG,Sun J
32-5600 was used in Western Blotting to study the role of the vitamin D receptor in lung barrier integrity.
Mon Apr 01 00:00:00 UTC 2019
TiHo-0906: a new feline mammary cancer cell line with molecular, morphological, and immunocytological characteristics of epithelial to mesenchymal transition.
Scientific reports
Granados-Soler JL,Junginger J,Hewicker-Trautwein M,Bornemann-Kolatzki K,Beck J,Brenig B,Betz D,Schille JT,Murua Escobar H,Nolte I
32-5600 was used in Immunohistochemistry to present excellent opportunities for studying EMT on FMCs.
Wed Sep 05 00:00:00 UTC 2018
Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice.
Brain, behavior, and immunity
de Sousa Rodrigues ME,Bekhbat M,Houser MC,Chang J,Walker DI,Jones DP,Oller do Nascimento CMP,Barnum CJ,Tansey MG
325600 was used in immunohistochemistry and western blot to explore the effects of mild chronic psychological stress on metabolic, inflammatory, and behavioral profiles in a mouse model of diet-induced obesity
Sun Jan 01 00:00:00 UTC 2017
Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells.
PloS one
Tokuda S,Hirai T,Furuse M
32-5600 was used in Immunocytochemistry-immunoflourescence to establish claudin-4 knockout clones in MDCK II cells and investigate the permeability property of claudin-4.
Tue Oct 10 00:00:00 UTC 2017
The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice.
Biochemical pharmacology
Ocón B,Aranda CJ,Gámez-Belmonte R,Suárez MD,Zarzuelo A,Martínez-Augustin O,Sánchez de Medina F
325600 was used in western blot to evaluate the effect of glucocorticoids in a mouse model of colitis
Thu Sep 15 00:00:00 UTC 2016
Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs.
Molecular medicine reports
Ahn C,Shin DH,Lee D,Kang SM,Seok JH,Kang HY,Jeung EB
325600 was used in immunohistochemistry - paraffin section and western blot to measure tight junction protein expression in canine duodenum, lung, liver, and kidney
Sat Oct 01 00:00:00 UTC 2016
Mechanisms Involved in the Development of the Chronic Gastrointestinal Syndrome in Nonhuman Primates after Total-Body Irradiation with Bone Marrow Shielding.
Radiation research
Shea-Donohue T,Fasano A,Zhao A,Notari L,Yan S,Sun R,Bohl JA,Desai N,Tudor G,Morimoto M,Booth C,Bennett A,Farese AM,MacVittie TJ
325600 was used in western blot to study a nonhuman primate model of chronic gastrointestinal syndrome
Wed Jun 01 00:00:00 UTC 2016
A microwave antigen retrieval method using two heating steps for enhanced immunostaining on aldehyde-fixed paraffin-embedded tissue sections.
Histochemistry and cell biology
Gu L,Cong J,Zhang J,Tian YY,Zhai XY
32-5600 was used in immunohistochemistry - paraffin section to utilize a microwave antigen retrieval method by using two heating steps for enhanced immunostaining on tissue sections that are aldehyde-fixed and paraffin-embedded
Wed Jun 01 00:00:00 UTC 2016
Claudin-2 Expression Levels in Ulcerative Colitis: Development and Validation of an In-Situ Hybridisation Assay for Therapeutic Studies.
PloS one
Randall K,Henderson N,Reens J,Eckersley S,Nyström AC,South MC,Balendran CA,Böttcher G,Hughes G,Price SA
32-5600 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot establish methods to assess claudin-2 expression and localization in human colon biopsy samples
Wed Aug 02 00:00:00 UTC 2017
Expression of Tight Junction Proteins and Cadherin 17 in the Small Intestine of Young Goats Offered a Reduced N and/or Ca Diet.
PloS one
Elfers K,Marr I,Wilkens MR,Breves G,Langeheine M,Brehm R,Muscher-Banse AS
32-5600 was used in western blot to characterize a reduced N and/or Ca diet by expression of tight junction proteins and cadherin 17 in the small intestine of young goats
Mon Mar 27 00:00:00 UTC 2017
Effects of Osmolality on Paracellular Transport in MDCK II Cells.
PloS one
Tokuda S,Hirai T,Furuse M
32-5600 was used in Immunocytochemistry-immunoflourescence to show that osmotic gradient between apical and basal sides is involved in the acute regulation of the cation selective property of claudin-2 channels.
Mon Jun 26 00:00:00 UTC 2017
POF1B localizes to desmosomes and regulates cell adhesion in human intestinal and keratinocyte cell lines.
The Journal of investigative dermatology
Crespi A,Bertoni A,Ferrari I,Padovano V,Della Mina P,Berti E,Villa A,Pietrini G
32-5600 was used in western blot to investigate the localization of POF1B in desmosomes and its role in human intestinal and keratinocyte cell lines
Thu Jan 01 00:00:00 UTC 2015
EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells.
Journal of cellular physiology
García-Hernández V,Flores-Maldonado C,Rincon-Heredia R,Verdejo-Torres O,Bonilla-Delgado J,Meneses-Morales I,Gariglio P,Contreras RG
32-5600 was used in immunocytochemistry and western blot to investigate the effect of EGF on claudin-2 and -4 expression in MDCK cells.
Thu Jan 01 00:00:00 UTC 2015
TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Freeman JJ,Feng Y,Demehri FR,Dempsey PJ,Teitelbaum DH
32-5600 was used in immunocytochemistry to study the modulatory effect of TLR4/EGF signaling pathways on TPN-associated intestinal epithelial cell atrophy.
Wed Jul 01 00:00:00 UTC 2015
Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Watari A,Hashegawa M,Yagi K,Kondoh M
32-5600 was used in western blot to investigate the effect of homoharringtonine on intestinal epithelial permeability and its mechanism
Thu Jan 01 00:00:00 UTC 2015
Tumor necrosis factor-α induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions.
American journal of physiology. Cell physiology
Amoozadeh Y,Dan Q,Xiao J,Waheed F,Szászi K
Wed Jul 01 00:00:00 UTC 2015
The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment.
American journal of physiology. Gastrointestinal and liver physiology
de Vallière C,Vidal S,Clay I,Jurisic G,Tcymbarevich I,Lang S,Ludwig MG,Okoniewski M,Eloranta JJ,Kullak-Ublick GA,Wagner CA,Rogler G,Seuwen K
32-5600 was used in western blot to study OGR1-mediated, pH-dependent signaling pathways in intestinal epithelial cells.
Tue Sep 15 00:00:00 UTC 2015
(-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity.
Archives of biochemistry and biophysics
Contreras TC,Ricciardi E,Cremonini E,Oteiza PI
32-5600 was used in western blot to study the efficacy of (-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity.
Fri May 01 00:00:00 UTC 2015
A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.
Molecular biology of the cell
Van Itallie CM,Tietgens AJ,Krystofiak E,Kachar B,Anderson JM
32-5600 was used in immunocytochemistry and western blot to investigate the interaction between ZO-1 and TOCA-1
Sat Aug 01 00:00:00 UTC 2015
Effects of Hydrostatic Pressure on Carcinogenic Properties of Epithelia.
PloS one
Tokuda S,Kim YH,Matsumoto H,Muro S,Hirai T,Mishima M,Furuse M
32-5600 was used in Immunocytochemistry-immunoflourescence to indicate the role of the hydrostatic pressure gradient in the regulation of various epithelial cell functions.
Mon Jun 27 00:00:00 UTC 2016
TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells.
Nature immunology
Gerlach K,Hwang Y,Nikolaev A,Atreya R,Dornhoff H,Steiner S,Lehr HA,Wirtz S,Vieth M,Waisman A,Rosenbauer F,McKenzie AN,Weigmann B,Neurath MF
32-5600 was used in western blot to study the role of TH9 cells in ulcerative colitis
Tue Jul 01 00:00:00 UTC 2014
Innate immune factors in the development and maintenance of pouchitis.
Inflammatory bowel diseases
Landy J,Al-Hassi HO,Ronde E,English NR,Mann ER,Bernardo D,Ciclitira PJ,Clark SK,Knight SC,Hart AL
32-5600 was used in flow cytometry to perform longitudinal and cross-sectional studies of patients after restorative proctocolectomy and assess tight junction proteins and dendritic cell characteristics in the ileal pouch
Sat Nov 01 00:00:00 UTC 2014
Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel.
Toxicology and applied pharmacology
Wilmes A,Aschauer L,Limonciel A,Pfaller W,Jennings P
32-5600 was used in immunocytochemistry and western blot to evaluate claudin 2 as a proximal tubular stress responsive paracellular water channel
Mon Sep 01 00:00:00 UTC 2014
Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration.
Cellular microbiology
Glotfelty LG,Zahs A,Hodges K,Shan K,Alto NM,Hecht GA
32-5600 was used in immunocytochemistry to assess the contribution of enteropathogenic Escherichia coli EspG-mediated microtubule disruption to tight junction perturbation
Mon Dec 01 00:00:00 UTC 2014
Claudins as prognostic factors for renal cell cancer.
Anticancer research
Virman J,Soini Y,Kujala P,Luukkaala T,Salminen T,Sunela K,Kellokumpu-Lehtinen PL
32-5600 was used in immunohistochemistry - paraffin section to correlate claudin 1-5 and 7 expression with the survival, grade, and stage of patients with renal cell cancer
Fri Aug 01 00:00:00 UTC 2014
A CLDN1-negative phenotype predicts poor prognosis in triple-negative breast cancer.
PloS one
Ma F,Ding X,Fan Y,Ying J,Zheng S,Lu N,Xu B
32-5600 was used in immunohistochemistry to correlate expression of claudins with clinical outcomes of triple-negative breast cancer
Mon Jul 06 00:00:00 UTC 2015
Toll-like receptor 2 regulates the barrier function of human bronchial epithelial monolayers through atypical protein kinase C zeta, and an increase in expression of claudin-1.
Tissue barriers
Ragupathy S,Esmaeili F,Paschoud S,Sublet E,Citi S,Borchard G
32-5600 was used in immunocytochemistry to assess the role of Toll-like receptor 2 in maintaining the integrity of the airway epithelial barrier
Thu Aug 07 00:00:00 UTC 2014
ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape.
PloS one
Tokuda S,Higashi T,Furuse M
32-5600 was used in immunocytochemistry and western blot to characterize the TALEN-mediated ZO-1 knockout in MDCK cells
Wed May 13 00:00:00 UTC 2015
SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis.
EMBO molecular medicine
Fu Y,Huang B,Shi Z,Han J,Wang Y,Huangfu J,Wu W
32-5600 was used in Immunohistochemistry to suggest that promoting degradation and blocking production of β-catenin synergistically reduce β-catenin levels under pathological conditions.
Wed May 01 00:00:00 UTC 2013
Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis.
The American journal of pathology
Bergmann KR,Liu SX,Tian R,Kushnir A,Turner JR,Li HL,Chou PM,Weber CR,De Plaen IG
32-5600 was used in immunohistochemistry (frozen), immunohistochemistry - paraffin section, and western blot to study the effects of intestinal barrier proteins in necrotizing enterocolitis and test if Bifidobacterium infantis modulates tight junction proteins.
Wed May 01 00:00:00 UTC 2013
Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.
The American journal of pathology
Kissoon-Singh V,Moreau F,Trusevych E,Chadee K
32-5600 was used in immunohistochemistry (frozen) to examine innate responses to Entamoeba histolytica in wild-type and MUC-2-deficient mice.
Fri Mar 01 00:00:00 UTC 2013
Delineation of the key aspects in the regulation of epithelial monolayer formation.
Molecular and cellular biology
Aschauer L,Gruber LN,Pfaller W,Limonciel A,Athersuch TJ,Cavill R,Khan A,Gstraunthaler G,Grillari J,Grillari R,Hewitt P,Leonard MO,Wilmes A,Jennings P
Mon Jul 01 00:00:00 UTC 2013
Delineation of the key aspects in the regulation of epithelial monolayer formation.
Molecular and cellular biology
Aschauer L,Gruber LN,Pfaller W,Limonciel A,Athersuch TJ,Cavill R,Khan A,Gstraunthaler G,Grillari J,Grillari R,Hewitt P,Leonard MO,Wilmes A,Jennings P
Mon Jul 01 00:00:00 UTC 2013
Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis.
Human pathology
Lappi-Blanco E,Lehtonen ST,Sormunen R,Merikallio HM,Soini Y,Kaarteenaho RL
32-5600 was used in immunohistochemistry (paraffin) to examine tight junction and adherens junction proteins in normal human lung, IPF, cryptogenic organizing pneumonia, and asbestosis.
Wed May 01 00:00:00 UTC 2013
Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin.
International journal of clinical and experimental pathology
Hintsala HR,Siponen M,Haapasaari KM,Karihtala P,Soini Y
Mon Aug 04 00:00:00 UTC 2014
Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells.
Archives of toxicology
Limonciel A,Wilmes A,Aschauer L,Radford R,Bloch KM,McMorrow T,Pfaller W,van Delft JH,Slattery C,Ryan MP,Lock EA,Jennings P
32-5600 was used in immunocytochemistry and western blot to determine the effects of KBrO(3) using human and rat proximal tubular cell lines.
Thu Nov 01 00:00:00 UTC 2012
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
Journal of cell science
Guillemot L,Schneider Y,Brun P,Castagliuolo I,Pizzuti D,Martines D,Jond L,Bongiovanni M,Citi S
32-5600 was used in Western Blotting to conclude that cingulin is dispensable for tight junction structure and barrier function, and is embedded in signalling networks controlling claudin-2 expression.
Thu Nov 01 00:00:00 UTC 2012
Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumour-elicited macrophages in vivo.
Scandinavian journal of immunology
Van den Bossche J,Laoui D,Morias Y,Movahedi K,Raes G,De Baetselier P,Van Ginderachter JA
32-5600 was used in flow cytometry and western blot to identify Cldn1, Cldn2 and Cldn11 as genes that discriminate between diverse types of M2.
Fri Jun 01 00:00:00 UTC 2012
EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.
Developmental biology
Lei Z,Maeda T,Tamura A,Nakamura T,Yamazaki Y,Shiratori H,Yashiro K,Tsukita S,Hamada H
32-5600 was used in immunohistochemistry - frozen section, immunoprecipitation, and western blot to report that mice lacking EpCAM have intestinal barrier defects and die shortly after birth as a result of intestinal erosion.
Thu Nov 15 00:00:00 UTC 2012
Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells.
Molecular biology of the cell
Dukes JD,Fish L,Richardson JD,Blaikley E,Burns S,Caunt CJ,Chalmers AD,Whitley P
Thu Sep 01 00:00:00 UTC 2011
Enhanced immunohistochemical resolution of claudin proteins in glycolmethacrylate-embedded tissue biopsies.
Methods in molecular biology (Clifton, N.J.)
Collins JE,Kirk A,Campbell SK,Mason J,Wilson SJ
Fri Nov 04 00:00:00 UTC 2011
Differential expression of claudin tight junction proteins in the human cortical nephron.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Kirk A,Campbell S,Bass P,Mason J,Collins J
Thu Jul 01 00:00:00 UTC 2010
Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma.
Oncology reports
Kojima F,Ishida M,Takikita-Suzuki M,Hotta M,Katsura K,Nagata A,Enoki Y,Kato G,Okabe H
32-5600 was used in immunohistochemistry - paraffin section to determine claudin expression profiles in Epstein-Barr virus-associated non-keratinizing nasopharyngeal carcinoma
Thu Apr 01 00:00:00 UTC 2010
Differential gene expression in normal esophagus and Barrett's esophagus.
Journal of gastroenterology
Wang J,Qin R,Ma Y,Wu H,Peters H,Tyska M,Shaheen NJ,Chen X
32-5600 was used in Immunohistochemistry to study the role of CDX1 and CDX2 in the development of Barrett's esophagus in humans.
Tue Jan 19 00:00:00 UTC 2010
Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Kaarteenaho-Wiik R,Soini Y
325600 was used in immunohistochemistry - paraffin section to report the expression of various claudins in patients with sarcoidosis, usual interstitial pneumonia, and normal human lung
Sun Mar 01 00:00:00 UTC 2009
Claudin expression in rectal well-differentiated endocrine neoplasms (carcinoid tumors).
Oncology reports
Ishida M,Kushima R,Okabe H
32-5600 was used in immunohistochemistry - paraffin section to determine the expression of several different claudins in rectal well-differentiated endocrine neoplasms
Thu Jan 01 00:00:00 UTC 2009
Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells.
Histochemistry and cell biology
Son S,Kojima T,Decaens C,Yamaguchi H,Ito T,Imamura M,Murata M,Tanaka S,Chiba H,Hirata K,Sawada N
32-5600 was used in immunocytochemistry to study the role of claudin-2 in bile canalicular formation
Sun Mar 01 00:00:00 UTC 2009
Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes.
Liver international : official journal of the International Association for the Study of the Liver
Kojima T,Takano K,Yamamoto T,Murata M,Son S,Imamura M,Yamaguchi H,Osanai M,Chiba H,Himi T,Sawada N
32-5600 was used in immunocytochemistry to determine whether transforming growth factor-beta down-regulates claudin-1 expression to induce epithelial to mesenchymal transition
Tue Apr 01 00:00:00 UTC 2008
The keratin-binding protein Albatross regulates polarization of epithelial cells.
The Journal of cell biology
Sugimoto M,Inoko A,Shiromizu T,Nakayama M,Zou P,Yonemura S,Hayashi Y,Izawa I,Sasoh M,Uji Y,Kaibuchi K,Kiyono T,Inagaki M
32-5600 was used in western blot to elucidate how the keratin intermediate filament network is involved in the establishment and maintenance of cell polarity
Mon Oct 06 00:00:00 UTC 2008
Down-regulation of claudin-2 in breast carcinomas is associated with advanced disease.
Histopathology
Kim TH,Huh JH,Lee S,Kang H,Kim GI,An HJ
32-5600 was used in immunohistochemistry - paraffin section to study the role of CLDN2 expression in breast cancer development and progression
Tue Jul 01 00:00:00 UTC 2008
Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation.
Laboratory investigation; a journal of technical methods and pathology
Weber CR,Nalle SC,Tretiakova M,Rubin DT,Turner JR
32-5600 was used in immunohistochemistry - paraffin section to test if altered expression of intestinal epithelial tight junction proteins contributes to neoplastic progression
Wed Oct 01 00:00:00 UTC 2008
Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
Molecular membrane biology
Paschoud S,Citi S
32-5600 was used in western blot to study the effects of cingulin overexpression
Tue Jan 01 00:00:00 UTC 2008
Cholestasis is a marker for hepatocellular carcinomas displaying beta-catenin mutations.
The Journal of pathology
Audard V,Grimber G,Elie C,Radenen B,Audebourg A,Letourneur F,Soubrane O,Vacher-Lavenu MC,Perret C,Cavard C,Terris B
32-5600 was used in immunohistochemistry (paraffin) to correlate glutamine synthetase immunostaining and beta-catenin mutations with clinicopathological features in hepatocellular carcinomas.
Sun Jul 01 00:00:00 UTC 2007
Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura.
Journal of clinical pathology
Soini Y,Kinnula V,Kahlos K,Pääkkö P
32-5600 was used in immunohistochemistry - paraffin section to observe the expression of claudins in mesothelioma and metastatic pleural adenocarcinoma
Wed Mar 01 00:00:00 UTC 2006
Epithelial barrier characteristics and expression of cell adhesion molecules in proximal tubule-derived cell lines commonly used for in vitro toxicity studies.
Toxicology in vitro : an international journal published in association with BIBRA
Prozialeck WC,Edwards JR,Lamar PC,Smith CS
32-5600 was used in immunocytochemistry to characterize cell lines that mimic the characteristics of the proximal tubule
Fri Sep 01 00:00:00 UTC 2006
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 UTC 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 UTC 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 UTC 2003
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture.
American journal of physiology. Cell physiology
Colegio OR,Van Itallie C,Rahner C,Anderson JM
Sun Jun 01 00:00:00 UTC 2003
