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Clusterin alpha Polyclonal Antibody

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View all (4) Clusterin Alpha antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

OSC00286W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:2,000
-

Immunohistochemistry (IHC)

1:200-1:2,000
-

Miscellaneous PubMed (MISC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 400-448 of mouse Clusterin conjugated to an immunogenic carrier protein was used as the antigen
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: Clusterin alpha chain.

Target Information

Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Apo-J; Apolipoprotein J; Clusterin; Clustrin; complement lysis inhibitor; DAG; Dimeric acid glycoprotein; SGP-2; Sulfated glycoprotein 2; testosterone repressed prostate message; Testosterone repressed prostate message 2; testosterone repressed prostate message-2; testosterone-repressed prostate message; testostrone-repressed prostate message 2; TRPM-2

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Gene Aliases: AI893575; APOJ; CLI; Clu; D14Ucla3; DAG; Msgp-2; RATTRPM2B; SGP-2; SGP2; SP-40; SP40; Sugp-2; TRPM-2; Trpm2; TRPM2B; Trpmb

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UniProt ID: (Rat) P05371, (Mouse) Q06890

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Entrez Gene ID: (Rat) 24854, (Mouse) 12759

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Function(s)
protein binding ATPase activity ubiquitin protein ligase binding protein N-terminus binding misfolded protein binding
Process(es)
cell morphogenesis microglial cell activation response to oxidative stress spermatogenesis aging positive regulation of cell proliferation response to light stimulus response to wounding response to virus protein import endocrine pancreas development central nervous system myelin maintenance positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of protein homooligomerization positive regulation of tumor necrosis factor production response to potassium ion positive regulation of apoptotic process negative regulation of apoptotic process estrous cycle positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation neuron projection morphogenesis protein stabilization positive regulation of NF-kappaB transcription factor activity chaperone-mediated protein complex assembly response to misfolded protein chaperone-mediated protein folding microglial cell proliferation cellular response to growth factor stimulus intrinsic apoptotic signaling pathway regulation of beta-amyloid clearance regulation of neuron death positive regulation of neuron death positive regulation of beta-amyloid formation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of beta-amyloid formation regulation of neuronal signal transduction positive regulation of tau-protein kinase activity positive regulation of neurofibrillary tangle assembly positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of intrinsic apoptotic signaling pathway cell death
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