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AbboMax
Coagulation Factor VIII (Cleaved form, C-Term) Polyclonal Antibody
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Coagulation Factor VIII (Cleaved form, C-Term) Antibody (601-970) in WB
Western Blot: The whole lysate derived from Hepatocyte tissue (20 µg/lane) immunoblotted by Rabbit anti – FVIII (CT) antibody (Cat# 601-970) at 1:1000. Observed a major immunoreactive band at molecular weight ~80 kDa.
Product Details
601-970
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to C-term of the cleavage form around sequence EITRTTLQS of human FVIII protein
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Positive control: Human colon carcinoma
Cellular location: Secreted, extracellular space.
Target Information
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AHF; Antihemophilic factor; Coagulation factor VIII; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIIIc; Factor 8; factor VIII F8B; factor8; Procoagulant component; RP11-115M6.7
Gene Aliases: AHF; DXS1253E; F8; F8B; F8C; FVIII; HEMA
UniProt ID: (Human) P00451
Entrez Gene ID: (Human) 2157
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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