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Cofilin Polyclonal Antibody

Cofilin Antibody in Immunocytochemistry (ICC/IF)

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Cofilin Antibody (10960-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed NIH/3T3 cells using 10960-1-AP (Cofilin antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Cofilin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

10960-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:1,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 3 publications 3 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Cofilin Fusion Protein Ag1399 (1-166 aa encoded by BC012318)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASGVAVSD GVIKVFNDMK VRKSSTPEEV KKRKKAVLFC LSEDKKNIIL EEGKEILVGD VGQTVDDPYA TFVKMLPDKD CRYALYDATY ETKESKKEDL VFIFWAPESA PLKSKMIYAS SKDAIKKKLT GIKHELQANC YEEVKDRCTL AEKLGGSAVI SLEGKPL (1-166 aa encoded by BC012318)

Target Information

Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.

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TM9SF4 is an F-actin disassembly factor that promotes tumor progression and metastasis.

Nature communications

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Thu Sep 29 00:00:00 UTC 2022

NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration.

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Protein Kinase C Activation Drives a Differentiation Program in an Oligodendroglial Precursor Model through the Modulation of Specific Biological Networks.

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Sat May 15 00:00:00 UTC 2021

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JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.

Andrology

Liu K,Cui K,Feng H,Li R,Lin H,Chen Y,Zhang Y,Chen Z,Yuan H,Li M,Wang T,Lan R,Liu J,Rao K,Wen B

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Carbonic Anhydrase XII Expression Is Modulated during Epithelial Mesenchymal Transition and Regulated through Protein Kinase C Signaling.

International journal of molecular sciences

Vergara D,Ravaioli S,Fonzi E,Adamo L,Damato M,Bravaccini S,Pirini F,Gaballo A,Barbano R,Pasculli B,Franck J,Fournier I,Salzet M,Maffia M

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Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.

Cancer medicine

Zhang X,Fang J,Chen S,Wang W,Meng S,Liu B

Sun Sep 01 00:00:00 UTC 2019

Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.

Andrologia

Cui K,Li R,Chen R,Li M,Wang T,Yang J,Chen Z,Wang S,Liu J,Rao K

Thu Feb 01 00:00:00 UTC 2018

Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.

Andrologia

Cui K,Li R,Chen R,Li M,Wang T,Yang J,Chen Z,Wang S,Liu J,Rao K

Thu Feb 01 00:00:00 UTC 2018

Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1.

Asian journal of andrology

Cui K,Luan Y,Wang T,Zhuan L,Rao K,Wang SG,Ye ZQ,Liu JH,Wang DW

Mon Feb 27 00:00:00 UTC 2017

Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1.

Asian journal of andrology

Cui K,Luan Y,Wang T,Zhuan L,Rao K,Wang SG,Ye ZQ,Liu JH,Wang DW

Mon Feb 27 00:00:00 UTC 2017

NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.

Cell research

Zhang C,Zhang W,Lu Y,Yan X,Yan X,Zhu X,Liu W,Yang Y,Zhou T

Mon Feb 01 00:00:00 UTC 2016

NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.

Cell research

Zhang C,Zhang W,Lu Y,Yan X,Yan X,Zhu X,Liu W,Yang Y,Zhou T

Mon Feb 01 00:00:00 UTC 2016

NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.

Cell research

Zhang C,Zhang W,Lu Y,Yan X,Yan X,Zhu X,Liu W,Yang Y,Zhou T

Mon Feb 01 00:00:00 UTC 2016

NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.

Cell research

Zhang C,Zhang W,Lu Y,Yan X,Yan X,Zhu X,Liu W,Yang Y,Zhou T

Mon Feb 01 00:00:00 UTC 2016

The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy.

Oncology reports

Wu Q,Jiang Y,Cui S,Wang Y,Wu X

Sun May 01 00:00:00 UTC 2016

The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy.

Oncology reports

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Biochemical and biophysical research communications

Zan J,An ST,Mo KK,Zhou JW,Liu J,Wang HL,Yan Y,Liao M,Zhou JY

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Biochemical and biophysical research communications

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Rabies virus inactivates cofilin to facilitate viral budding and release.

Biochemical and biophysical research communications

Zan J,An ST,Mo KK,Zhou JW,Liu J,Wang HL,Yan Y,Liao M,Zhou JY

Fri Sep 02 00:00:00 UTC 2016

Rabies virus inactivates cofilin to facilitate viral budding and release.

Biochemical and biophysical research communications

Zan J,An ST,Mo KK,Zhou JW,Liu J,Wang HL,Yan Y,Liao M,Zhou JY

Fri Sep 02 00:00:00 UTC 2016

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Oncotarget

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A three-protein signature and clinical outcome in esophageal squamous cell carcinoma.

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Journal of proteome research

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Journal of proteome research

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Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma.

Journal of proteome research

Yang X,Zou P,Yao J,Yun D,Bao H,Du R,Long J,Chen X

Fri Mar 05 00:00:00 UTC 2010

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Journal of proteome research

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Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

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Bioinformatics

Protein Aliases: 18 kDa phosphoprotein; CFL-1; COF1; cofilin 1 (non-muscle); Cofilin, non-muscle isoform; Cofilin-1; Cofilin1; epididymis secretory protein Li 15; p18

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Gene Aliases: AA959946; CFL; CFL1; Cof; cofilin; HEL-S-15; n-cofilin

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UniProt ID: (Human) P23528, (Rat) P45592, (Mouse) P18760

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Entrez Gene ID: (Human) 1072, (Rat) 29271, (Mouse) 12631

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Function(s)

protein binding actin filament binding actin binding

Process(es)

cytoskeleton organization Rho protein signal transduction response to virus regulation of cell morphogenesis actin cytoskeleton organization actin filament depolymerization negative regulation of apoptotic process positive regulation by host of viral process regulation of dendritic spine morphogenesis mitotic cytokinesis neural crest cell migration neural fold formation protein phosphorylation protein import into nucleus actin filament organization establishment of cell polarity cell projection organization positive regulation of actin filament depolymerization response to amino acid negative regulation of cell size movement of cell or subcellular component

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Cofilin Polyclonal Antibody

Cofilin Antibody (10960-1-AP) in ICC/IF

Product Details

10960-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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