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Product Details
PA1-27399
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Collagen Type II extracted and purified from rat fetal cartilage.
Conjugate
Form
Liquid
Purification
Ion-exchange chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2245076
Product Specific Information
PA1-27399 detects Collagen II from rat samples.
Target Information
COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-1 type II collagen; CGA; Collagen 2; Collagen alpha-1(II) chain; collagen type II (Col2A1) gene, enhancer region; MGC131516; Procollagen II alpha 1; procollagen, type II, alpha 1
Gene Aliases: CG2A1A; Col2a1; COLLII
UniProt ID: (Rat) P05539
Entrez Gene ID: (Rat) 25412
skeletal system development
cartilage condensation
tissue homeostasis
endochondral ossification
chondrocyte differentiation
heart morphogenesis
growth plate cartilage development
proteoglycan metabolic process
central nervous system development
visual perception
sensory perception of sound
response to mechanical stimulus
response to X-ray
regulation of gene expression
collagen fibril organization
notochord development
limb morphogenesis
inner ear morphogenesis
skeletal system morphogenesis
inner ear development
cartilage development
palate development
limb bud formation
embryonic skeletal joint morphogenesis
bone development
cartilage development involved in endochondral bone morphogenesis
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to vitamin E
cellular response to nicotine
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
cellular response to peptide hormone stimulus
otic vesicle development
cellular response to BMP stimulus
response to fibroblast growth factor
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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