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Invitrogen
Collagen II Polyclonal Antibody
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Collagen II Antibody (PA5-85108) in IHC (P)
Collagen II Polyclonal Antibody detects Collagen II protein at cytoplasm in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. Collagen II Polyclonal Antibody (Product # PA5-85108) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-85108
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human Collagen II. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2792256
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (92%), Rat (96%), Xenopus laevis (91%), Dog (100%), Rabbit (100%), Chicken (95%), Bovine (100%).
Positive Control: HepG2 conditioned medium.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha-1 type II collagen; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; CGA; chondrocalcin; Collagen 2; Collagen alpha-1(II) chain; collagen II, alpha-1 polypeptide; collagen type II (Col2A1) gene, enhancer region; collagen, type II, alpha 1; disproportionate micromelia; MGC131516; Procollagen II alpha 1; procollagen, type II, alpha 1
Gene Aliases: ANFH; AOM; CG2A1A; COL11A3; Col2; Col2a; Col2a-1; COL2A1; COLLII; Del1; Dmm; Lpk; M100856; Rgsc856; SEDC; STL1
UniProt ID: (Human) P02458, (Rat) P05539, (Mouse) P28481
Entrez Gene ID: (Human) 1280, (Rat) 25412, (Mouse) 12824
skeletal system development
cartilage condensation
tissue homeostasis
endochondral ossification
chondrocyte differentiation
heart morphogenesis
growth plate cartilage development
proteoglycan metabolic process
central nervous system development
visual perception
sensory perception of sound
response to mechanical stimulus
response to X-ray
regulation of gene expression
collagen fibril organization
notochord development
limb morphogenesis
inner ear morphogenesis
skeletal system morphogenesis
inner ear development
cartilage development
palate development
limb bud formation
embryonic skeletal joint morphogenesis
bone development
cartilage development involved in endochondral bone morphogenesis
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to vitamin E
cellular response to nicotine
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
cellular response to peptide hormone stimulus
otic vesicle development
cellular response to BMP stimulus
response to fibroblast growth factor
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
extracellular matrix organization
collagen catabolic process
regulation of immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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