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Product Details
PA5-143803
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
The polyclonal antibody reacts with Rat C4
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3091723
Target Information
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c4 complement; Complement C4; complement C4-like protein; complement component 4 (within H-2S); complement component 4, gene 1; complement component 4, gene 2; complement component 4B (Chido blood group); complement component 4B (Childo blood group); DADB-112B14.11; DAMC-258G8.6; FLJ60561; MGC164979
Gene Aliases: C4; C4-1; C4-2; C4a; C4b; C4l
UniProt ID: (Rat) Q62895
Entrez Gene ID: (Rat) 24233, (Rat) 406161
inflammatory response
complement activation
biological_process
negative regulation of endopeptidase activity
immunoglobulin mediated immune response
detection of molecule of bacterial origin
positive regulation of apoptotic cell clearance
complement activation, classical pathway
innate immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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