Proteintech

Complement factor B Polyclonal Antibody

Complement factor B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

Complement factor B Antibody (10170-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver tissue slide using 10170-1-AP ( Complement factor B antibody at dilution of 1:50 (under 40x lens).

Complement factor B Antibody in Western Blot (WB)

Product Image Gallery

Product Details

10170-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Complement factor B Fusion Protein Ag0226 (573-761 aa encoded by BC007990)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody raised against 573-761aa of human complement factor B can recognize complement factor B and Bb fragment.

Immunogen sequence: YDYDVALIK LKNKLKYGQT IRPICLPCTE GTTRALRLPP TTTCQQQKEE LLPAQDIKAL FVSEEEKKLT RKEVYIKNGD KKGSCERDAQ YAPGYDKVKD ISEVVTPRFL CTGGVSPYAD PNTCRGDSGG PLIVHKRSRF IQVGVISWGV VDVCKNQKRQ KQVPAHARDF HINLFQVLPW LKEKLQDEDL (573-761 aa encoded by BC007990)

Target Information

Factor B is a component of the alternative complement pathway. The protein is a single chain polypeptide with a molecular mass of 93 kDa. Factor B is cleaved by factor D into the Ba component (30 kDa) and the Bb (63 kDa). Bb together with C3b forms the alternative pathway C3 convertase C3bBb.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The classical pathway triggers pathogenic complement activation in membranous nephropathy.

Nature communications

Seifert L,Zahner G,Meyer-Schwesinger C,Hickstein N,Dehde S,Wulf S,Köllner SMS,Lucas R,Kylies D,Froembling S,Zielinski S,Kretz O,Borodovsky A,Biniaminov S,Wang Y,Cheng H,Koch-Nolte F,Zipfel PF,Hopfer H,Puelles VG,Panzer U,Huber TB,Wiech T,Tomas NM

Sat Jan 28 00:00:00 UTC 2023

The influences of α-hemolytic Streptococcus on class switching and complement activation of human tonsillar cells in IgA nephropathy.

Immunologic research

Ye M,Wang C,Li L,Zhao Q,Peng Y,Liu H

Tue Feb 01 00:00:00 UTC 2022

Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer.

Cellular oncology (Dordrecht, Netherlands)

Shimazaki R,Takano S,Satoh M,Takada M,Miyahara Y,Sasaki K,Yoshitomi H,Kagawa S,Furukawa K,Takayashiki T,Kuboki S,Sogawa K,Motohashi S,Nomura F,Miyazaki M,Ohtsuka M

Sun Aug 01 00:00:00 UTC 2021

Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer.

Cellular oncology (Dordrecht, Netherlands)

Shimazaki R,Takano S,Satoh M,Takada M,Miyahara Y,Sasaki K,Yoshitomi H,Kagawa S,Furukawa K,Takayashiki T,Kuboki S,Sogawa K,Motohashi S,Nomura F,Miyazaki M,Ohtsuka M

Sun Aug 01 00:00:00 UTC 2021

Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer.

Cellular oncology (Dordrecht, Netherlands)

Shimazaki R,Takano S,Satoh M,Takada M,Miyahara Y,Sasaki K,Yoshitomi H,Kagawa S,Furukawa K,Takayashiki T,Kuboki S,Sogawa K,Motohashi S,Nomura F,Miyazaki M,Ohtsuka M

Sun Aug 01 00:00:00 UTC 2021

IL-1/IL-1R signaling induced by all-trans-retinal contributes to complement alternative pathway activation in retinal pigment epithelium.

Journal of cellular physiology

Cheng X,He D,Liao C,Lin S,Tang L,Wang YL,Hu J,Li W,Liu Z,Wu Y,Liao Y

Sat May 01 00:00:00 UTC 2021

The imbalance in the complement system and its possible physiological mechanisms in patients with lung cancer.

BMC cancer

Zhao P,Wu J,Lu F,Peng X,Liu C,Zhou N,Ying M

Wed Mar 06 00:00:00 UTC 2019

4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells.

Chemical research in toxicology

Linetsky M,Bondelid KS,Losovskiy S,Gabyak V,Rullo MJ,Stiadle TI,Munjapara V,Saxena P,Ma D,Cheng YS,Howes AM,Udeigwe E,Salomon RG

Mon Aug 20 00:00:00 UTC 2018

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

British journal of cancer

Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

Tue Mar 01 00:00:00 UTC 2016

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

British journal of cancer

Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

Tue Mar 01 00:00:00 UTC 2016

Resveratrol delays polycystic kidney disease progression through attenuation of nuclear factor κB-induced inflammation.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Wu M,Gu J,Mei S,Xu D,Jing Y,Yao Q,Chen M,Yang M,Chen S,Yang B,Qi N,Hu H,Wüthrich RP,Mei C

Tue Nov 01 00:00:00 UTC 2016

The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1.

American journal of physiology. Renal physiology

Wu M,Chen M,Jing Y,Gu J,Mei S,Yao Q,Zhou J,Yang M,Sun L,Wang W,Hu H,Wüthrich RP,Mei C

Wed Jun 01 00:00:00 UTC 2016

The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1.

American journal of physiology. Renal physiology

Wu M,Chen M,Jing Y,Gu J,Mei S,Yao Q,Zhou J,Yang M,Sun L,Wang W,Hu H,Wüthrich RP,Mei C

Wed Jun 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: B-factor, properdin; C3 proaccelerator; C3 proactivator; C3/C5 convertase; Complement factor B; DADB-122G4.5; GBG; Glycine-rich beta glycoprotein; glycine-rich beta-glycoprotein; PBF2; Properdin factor B

View more View less

Gene Aliases: AHUS4; ARMD14; BF; BFD; CFAB; CFB; CFBD; FB; FBI12; GBG; H2-Bf; PBF2

View more View less

UniProt ID: (Human) P00751

View more View less

Entrez Gene ID: (Human) 629

View more View less

Function(s)

complement binding serine-type endopeptidase activity

Process(es)

proteolysis complement activation complement activation, alternative pathway regulation of complement activation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

Complement factor B Polyclonal Antibody

Complement factor B Antibody (10170-1-AP) in IHC (P)

Product Details

10170-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!