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Invitrogen
Connexin 26 Polyclonal Antibody
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Connexin 26 Antibody (PA5-18618) in WB
Western blot was performed using Anti-Connexin 26 Polyclonal Antibody (Product # PA5-18618) and a 26 kDa band corresponding to Connexin 26 was observed across the cell lines and tissues tested. Membrane enriched extracts (30 µg lysate) of MCF7 (Lane 1), PANC-1 (Lane2), A-431 (Lane 3), SH-SY5Y (Lane 4), Daudi (Lane 5) and tissue extracts (30 µg lysate) of Mouse Adipose (Lane 6), Mouse Liver (Lane 7), Mouse Brain (Lane 8) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transfer... View More
Product Details
PA5-18618
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (YLLIRYCSGKSKKP) corresponding to the C-terminus amino acids of GJB2 (aa 212-225).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10982506
Product Specific Information
This antibody is predicted to react with human and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variables (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: connexin 26; Connexin-26; Cx26; Gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2; gap junction protein, beta 2, 26kDa; mutant gap junction protein beta 2
Gene Aliases: AI325222; Cnx26; CX26; CXN-26; DFNA3; DFNA3A; DFNB1; DFNB1A; Gjb-2; GJB2; HID; KID; NSRD1; PPK
UniProt ID: (Human) P29033, (Mouse) Q00977, (Rat) P21994
Entrez Gene ID: (Human) 2706, (Mouse) 14619, (Rat) 394266
cell communication
sensory perception of sound
gap junction assembly
transmembrane transport
cell-cell signaling
female pregnancy
male genitalia development
response to estradiol
response to progesterone
cellular response to oxidative stress
response to human chorionic gonadotropin
decidualization
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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