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Invitrogen
Coronin 3 Polyclonal Antibody
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Product Details
PA5-21775
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Coronin 1C. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152390
Product Specific Information
Recommended positive controls: A431, H1299, HeLa, HepG2.
Predicted reactivity: Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Coronin 3 is associated with the aggression and metastasis of hepatocellular carcinoma. Coronins are a family of highly evolutionary conserved proteins reportedly involved in the regulation of actin cytoskeletal dynamics, although only coronin 3 has been shown to be related to cancer cell migration.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: coronin 1c; coronin 3; coronin, actin binding protein, 1C; coronin, actin-binding protein, 1C; Coronin-1C; Coronin-3; hCRNN4
Gene Aliases: AL022675; AW455561; AW548837; CORO1C; CRN2; CRNN4; HCRNN4
UniProt ID: (Human) Q9ULV4, (Mouse) Q9WUM4
Entrez Gene ID: (Human) 23603, (Mouse) 23790
neural crest cell migration
regulation of protein phosphorylation
negative regulation of protein phosphorylation
phagocytosis
signal transduction
regulation of epithelial cell migration
negative regulation of epithelial cell migration
regulation of fibroblast migration
actin cytoskeleton organization
negative regulation of protein kinase activity by regulation of protein phosphorylation
establishment of protein localization
regulation of focal adhesion assembly
negative regulation of focal adhesion assembly
activation of GTPase activity
regulation of substrate adhesion-dependent cell spreading
negative regulation of substrate adhesion-dependent cell spreading
regulation of ruffle assembly
positive regulation of lamellipodium morphogenesis
actin cortical patch assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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