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QED Bioscience
Corticotropin Releasing Factor Monoclonal Antibody (4H9)
Product Details
56101-100UG
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4H9
Immunogen
Purified human/rat corticotropin-releasing factor (CRF, Sigma).
Conjugate
Form
Liquid
Concentration
0.5-1.0 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Corticotropin Releasing Factor (CRF), a 41 amino acids neuropeptide, belongs to a family of structurally related peptides including urocortin, sauvagine and urotensin I. CRF is critical in the regulation of the pituitary-adrenal gland axis, and in endocrine, autonomic and behavioral responses to stress. CRF is widely distributed in the brain and peripheral nervous system with the highest levels in the hypothalamic paraventricular nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Corticoliberin; Corticotropin-releasing factor; Corticotropin-releasing hormone; CRF
Gene Aliases: CRF; CRH; CRH1
UniProt ID: (Human) P06850, (Rat) P01143
Entrez Gene ID: (Human) 1392, (Rat) 81648
positive regulation of protein phosphorylation
synaptic transmission, dopaminergic
glucocorticoid biosynthetic process
inflammatory response
signal transduction
chemical synaptic transmission
female pregnancy
parturition
learning or memory
positive regulation of cell proliferation
associative learning
hormone-mediated apoptotic signaling pathway
positive regulation of gene expression
negative regulation of gene expression
negative regulation of norepinephrine secretion
positive regulation of circadian sleep/wake cycle, wakefulness
positive regulation of cell death
regulation of serotonin secretion
diterpenoid metabolic process
hypothalamus development
lung development
adrenal gland development
positive regulation of cAMP biosynthetic process
negative regulation of epinephrine secretion
negative regulation of luteinizing hormone secretion
locomotory exploration behavior
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to immobilization stress
negative regulation of circadian sleep/wake cycle, REM sleep
response to drug
response to estrogen
response to ethanol
response to ether
negative regulation of blood pressure
response to pain
ion homeostasis
response to corticosterone
positive regulation of corticotropin secretion
positive regulation of cortisol secretion
long-term synaptic potentiation
positive regulation of digestive system process
negative regulation of cell death
negative regulation of glucagon secretion
cellular response to cocaine
cellular response to dexamethasone stimulus
positive regulation of calcium ion import
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of corticosterone secretion
positive regulation of behavioral fear response
steroid metabolic process
response to cocaine
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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