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Invitrogen
Cripto Polyclonal Antibody
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Product Details
PA5-17191
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids near the amino terminus of mouse Cripto
Conjugate
Form
Liquid
Concentration
151 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10982191
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cripto growth factor; Cripto-1; Cripto-3; Epidermal growth factor-like Cripto protein; TDGF2; Teratocarcinoma-derived growth factor; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
Gene Aliases: CR1; Cripto; Tdgf1
UniProt ID: (Mouse) P51865
Entrez Gene ID: (Mouse) 21667
activation of MAPK activity
vasculogenesis
in utero embryonic development
morphogenesis of a branching structure
positive regulation of cell-matrix adhesion
cell migration involved in sprouting angiogenesis
epidermal growth factor receptor signaling pathway
gastrulation
heart development
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
anterior/posterior axis specification
regulation of signal transduction
positive regulation of endothelial cell migration
peptidyl-serine phosphorylation
cell differentiation
regulation of cell migration
positive regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
cellular response to hepatocyte growth factor stimulus
nodal signaling pathway
negative regulation of apoptotic process
cellular response to fibroblast growth factor stimulus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
cardiac muscle cell differentiation
canonical Wnt signaling pathway
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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