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Product Details
MA5-44005
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CSK-04
Immunogen
Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450
Conjugate
Form
Liquid
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2912937
Product Specific Information
This antibody reacts with Csk (C-terminal Src kinase), a 50 kDa intracellular non-receptor protein tyrosine kinase.
Immunoprecipitation: The immunosorbent (CSK-04 antibody covalently bound to beads) immunoprecipitants Csk from cell lysates.
Target Information
CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-Src kinase; MGC117393; p50CSK; Protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
Gene Aliases: AW212630; CSK; p50CSK
UniProt ID: (Human) P41240, (Mouse) P41241
Entrez Gene ID: (Human) 1445, (Mouse) 12988
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
protein C-terminus binding
kinase activity
protein phosphatase binding
protein kinase A catalytic subunit binding
identical protein binding
metal ion binding
proline-rich region binding
regulation of cytokine production
adaptive immune response
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
central nervous system development
brain development
negative regulation of cell proliferation
negative regulation of low-density lipoprotein particle clearance
cell migration
cell differentiation
T cell costimulation
negative regulation of interleukin-6 production
negative regulation of kinase activity
adherens junction organization
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
negative regulation of Golgi to plasma membrane protein transport
positive regulation of MAP kinase activity
innate immune response
negative regulation of bone resorption
oligodendrocyte differentiation
negative regulation of phagocytosis
T cell receptor signaling pathway
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of ERK1 and ERK2 cascade
cellular response to peptide hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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