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Product Details
26825-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CstF-64 Fusion Protein Ag25254 (408-504 aa encoded by BC017712)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RGIDARGME ARAMEARGLD ARGLEARAME ARAMEARAME ARAMEARAME VRGMEARGMD TRGPVPGPRG PIPSGMQGPS PINMGAVVPQ GSRQVPVM (408-504 aa encoded by BC017712)
Target Information
CSTF2 is one of three (including CSTF1 and CSTF3) cleavage stimulation factors which combine to form CSTF which is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. CSTF2 contains a ribonucleoprotein-type RNA binding domain. CSTF2 is upregulated during activation of B cells which results in the switch of IgM heavy chain mRNA from membrane bound form to the secreted form.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alphaCstF-64 variant 4; betaCstF-64 variant 1; betaCstF-64 variant 2; betaCstF-64 variant 3; CF-1 64 kDa subunit; Cleavage stimulation factor 64 kDa subunit; Cleavage stimulation factor subunit 2; cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa; cleavage stimulation factor, 3' pre-RNA, subunit 2; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kD; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa; CstF 64; CSTF 64 kDa subunit
Gene Aliases: C630034J23Rik; CstF-64; CSTF2; Cstf64; mir-3112
UniProt ID: (Human) P33240, (Mouse) Q8BIQ5
Entrez Gene ID: (Human) 1478, (Rat) 683927, (Mouse) 108062
mRNA splicing, via spliceosome
termination of RNA polymerase II transcription
mRNA polyadenylation
mRNA cleavage
tRNA splicing, via endonucleolytic cleavage and ligation
mRNA 3'-end processing
pre-mRNA cleavage required for polyadenylation
cellular response to nerve growth factor stimulus
mRNA processing
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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