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Product Details
100-401-A03
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cul3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the N-Terminal near amino acids 1-25 of Human Cul3 coupled to KLH.
Conjugate
Form
Liquid
Concentration
85 mg/mL
Storage buffer
whole serum
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This product reacts with human Cullin 3. Cross reactivity is expected against mouse Cul3 based on sequence homology. Cross reactivity with other human cullins is unlikely based on sequence homology.
Target Information
Cullin 3 is a member of the family of human cullin genes (CUL 1, 2, 3, 4a, 4b, and 5) homologous to the S. cerevisiae cdc 53 gene. CUL 1 forms a complex with human p19 skp1 and F box protein p45 skp2. Together with cdc 53 (Known as Cul A), as three subunits, they form a ubiquitin ligase-controlling proteolysis of G1 cell cycle regulatory proteins. In contrast to CUL 1, CUL 2 does not associate with p19 skp1 and p45 skp2. Instead, CUL 2 forms a complex with an inactive transcriptional elongation complex, SIII, formed by three subunits: Elongain C, Elongin B and VHL. The function of this association remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CUL-3; Cullin-3; OTTHUMP00000203839; OTTHUMP00000203840
Gene Aliases: AI467304; AW146203; CUL-3; CUL3; KIAA0617; mKIAA0617; PHA2E
UniProt ID: (Human) Q13618, (Mouse) Q9JLV5
Entrez Gene ID: (Human) 8452, (Mouse) 26554
negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
mitotic cell cycle
cell morphogenesis
in utero embryonic development
trophectodermal cellular morphogenesis
regulation of transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
protein monoubiquitination
transport
ER to Golgi vesicle-mediated transport
mitotic metaphase plate congression
integrin-mediated signaling pathway
gastrulation
negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
Wnt signaling pathway
vesicle-mediated transport
cell migration
protein ubiquitination
stem cell division
positive regulation of cytokinesis
negative regulation of Rho protein signal transduction
embryonic cleavage
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
stress fiber assembly
proteasome-mediated ubiquitin-dependent protein catabolic process
fibroblast apoptotic process
positive regulation of mitotic metaphase/anaphase transition
COPII vesicle coating
liver morphogenesis
G1/S transition of mitotic cell cycle
MAPK cascade
cell cycle arrest
positive regulation of cell proliferation
cell projection organization
negative regulation of canonical Wnt signaling pathway
intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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